人类CD123AXL树突状细胞表达Siglec1，其捕获HIV-1颗粒并将其传递给T细胞。

Human CD123AXL dendritic cells express Siglec1 that captures and transmits HIV-1 particles to the T cells.

作者信息

Yu Haisheng, Cao Yinghui, Cheng Liang, Li Guangming, Zhang Liguo, Su Lishan

机构信息

Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

出版信息

J Virus Erad. 2025 Feb 20;11(2):100587. doi: 10.1016/j.jve.2025.100587. eCollection 2025 Jun.

DOI:10.1016/j.jve.2025.100587

PMID:40213469

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982032/

Abstract

Human dendritic cells (DCs) are classified into three subsets based on their ontogeny, transcriptomes, and functions. During primary human immunodeficiency virus (HIV) infection, DCs in the peripheral tissues capture the HIV-1 particles, migrate to the lymph nodes, transfer the particles to CD4 T cells, and initiate infection. However, the identity of the DC subset involved is yet elusive. Hitherto, a novel subset (AXLDCs) has been identified in human blood, which is transcriptomically and functionally distinct from three known subsets. Compared to these, resting AXLDCs express Siglec1 (CD169), capture HIV-1 particles in a CD169-dependent manner, and mediate transinfection. These results suggested that AXL DCs may facilitate HIV-1 transmission and the spread of very early-stage HIV infection in patients. Therapeutic strategies that target AXLDCs or CD169 interaction with HIV-1 may provide pre-exposure protection during the initial stages of HIV-1 infection.

摘要

人类树突状细胞（DCs）根据其个体发生、转录组和功能可分为三个亚群。在原发性人类免疫缺陷病毒（HIV）感染期间，外周组织中的DCs捕获HIV-1颗粒，迁移至淋巴结，将颗粒传递给CD4 T细胞，并引发感染。然而，所涉及的DC亚群的身份仍不清楚。迄今为止，在人类血液中已鉴定出一种新型亚群（AXLDCs），其在转录组和功能上与三个已知亚群不同。与这些亚群相比，静息AXLDCs表达Siglec1（CD169），以CD169依赖性方式捕获HIV-1颗粒，并介导转染。这些结果表明，AXL DCs可能促进HIV-1传播以及患者极早期HIV感染的扩散。靶向AXLDCs或CD169与HIV-1相互作用的治疗策略可能在HIV-1感染的初始阶段提供暴露前保护。