Newsom B D, O'Neal R M, Heath B J
J Surg Res. 1985 Aug;39(2):133-9. doi: 10.1016/0022-4804(85)90170-2.
A canine external jugular vein to iliac artery interposition model was devised to evaluate the potential deleterious effects of cold potassium cardioplegic solution exposure to saphenous vein grafts during aortocoronary bypass procedures. The right jugular vein was harvested from 11 animals and halved, one segment being perfused with 1 liter of normal saline solution (NS) at 4 degrees C over a period of 31.7 +/- 2.5 min at a perfusion pressure of 50.5 +/- 2.6 mm Hg, and the other segment perfused with 1 liter of crystalloid potassium cardioplegic solution (CP) at 4 degrees C over a period of 24.8 +/- 3.2 min at a perfusion pressure of 53.0 +/- 1.5 mm Hg. The measured differences in the perfusion times and pressures were not significant at P less than 0.05. The grafts were then interposed into the iliac artery systems of their respective animals, and transgraft pressure gradients were measured by direct needle puncture technique and found to be 12.6 +/- 5.9 mm Hg for the CP-treated grafts and 19.9 +/- 9.6 mm Hg for the NS-treated grafts. At the time of graft harvest 7.4 +/- 0.23 months later transgraft pressure gradients were again measured and found to be 2.5 +/- 1.8 mm Hg for the CP-treated and 2.9 +/- 1.7 mm Hg for the NS-treated grafts.(ABSTRACT TRUNCATED AT 250 WORDS)
设计了一种犬颈外静脉至髂动脉搭桥模型，以评估在主动脉冠状动脉搭桥手术期间，冷钾心脏停搏液暴露于大隐静脉移植物的潜在有害影响。从11只动物身上取下右颈静脉并分成两半，一段在4℃下以50.5±2.6mmHg的灌注压用1升生理盐水（NS）灌注31.7±2.5分钟，另一段在4℃下以53.0±1.5mmHg的灌注压用1升晶体钾心脏停搏液（CP）灌注24.8±3.2分钟。所测得的灌注时间和压力差异在P<0.05时无统计学意义。然后将移植物植入各自动物的髂动脉系统，通过直接针刺技术测量跨移植物压力梯度，发现CP处理的移植物为12.6±5.9mmHg，NS处理的移植物为19.9±9.6mmHg。在7.4±0.23个月后取移植物时，再次测量跨移植物压力梯度，发现CP处理的移植物为2.5±1.8mmHg，NS处理的移植物为2.9±1.7mmHg。（摘要截短于250字）
