Starr Lynn, Dutta Sanjoy, Danne Thomas, Karpen Stephen R, Hutton Campbell, Kowalski Aaron
Breakthrough T1D, 1400 K St. NW Suite 1200, Washington, DC, 20005, USA.
Breakthrough T1D, 200 Vesey Street, 28th Floor, New York, NY, 10281, USA.
Diabetes Ther. 2025 Jun;16(6):1063-1076. doi: 10.1007/s13300-025-01735-6. Epub 2025 Apr 11.
Despite significant progress, type 1 diabetes (T1D) still results in premature death, significant complications, and a substantial daily burden for those affected. T1D remains a lifelong condition that demands constant vigilance and resilience and has a significant social and economic impact. Individuals with T1D must walk a tightrope to minimize disease-related complications that result from insufficient insulin while also avoiding adverse effects from too much insulin. Achieving this balance is challenging, as diet, activity, medications, physiology, the environment, stress, and many other aspects of daily living all affect glucose levels, often differently from day to day. Persistent challenges of T1D go beyond maintaining glycemic control and include managing long-term complications and preventing potentially life-threating adverse reactions from insulin therapy, and the emotional and cognitive burdens that often lead to diabetes distress and burnout. The T1D community-researchers, sponsors, clinicians, those living with T1D, and advocates-must look beyond managing symptoms of T1D and aim for better treatments and to bring cures. Emerging therapies need clear and efficient regulatory pathways, and new solutions are needed to address ongoing regulatory challenges. The perspectives of people with T1D must be front and center in research and regulatory decision-making. Through the collective efforts of the T1D community, the urgent needs of those with T1D can be met, and T1D can be made a thing of the past.
尽管取得了重大进展，但1型糖尿病（T1D）仍然会导致过早死亡、严重并发症，并给患者带来沉重的日常负担。T1D仍是一种终身疾病，需要持续的警惕和适应能力，并且会产生重大的社会和经济影响。患有T1D的个体必须小心翼翼，以尽量减少因胰岛素不足导致的与疾病相关的并发症，同时还要避免因胰岛素过量产生的不良反应。实现这种平衡具有挑战性，因为饮食、活动、药物、生理状况、环境、压力以及日常生活的许多其他方面都会影响血糖水平，而且常常每天都有所不同。T1D持续存在的挑战不仅限于维持血糖控制，还包括管理长期并发症、预防胰岛素治疗可能危及生命的不良反应，以及应对常常导致糖尿病困扰和倦怠的情绪和认知负担。T1D群体——研究人员、赞助商、临床医生、T1D患者以及倡导者——必须超越T1D症状的管理，致力于更好的治疗方法并寻求治愈方案。新兴疗法需要清晰有效的监管途径，并且需要新的解决方案来应对持续存在的监管挑战。T1D患者的观点必须在研究和监管决策中处于首要和核心位置。通过T1D群体的共同努力，T1D患者的迫切需求能够得到满足，T1D也能够成为历史。
