Borba Victoria Zeghbi Cochenski, Costa Tatiana Munhoz da Rocha Lemos
Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná - SEMPR, Curitiba, PR, Brasil.
Arch Endocrinol Metab. 2025 Apr 11;68:e240084. doi: 10.20945/2359-4292-2024-0084.
The global increase in life expectancy has led to a concomitant rise in diagnoses of sarcopenia. At the same time, the epidemic levels of obesity have given rise to the emergence of a complex condition known as sarcopenic obesity. Characterized by the simultaneous presence of loss of muscle mass and strength along with obesity or excess body fat, sarcopenic obesity represents a concerning health condition. Contrary to prevailing assumptions, sarcopenic obesity is not exclusive to older adults, as it may also manifest in individuals with obesity and chronic diseases and in those who undergo rapid weight loss. This juxtaposition of fat accumulation and muscle depletion epitomizes a harmful combination, especially in healthy adults. A precise definition of sarcopenic obesity and an understanding of how different body composition components affect functional parameters, comorbidities, and mortality rates are crucial for grasping the full extent and significance of this condition. Despite its multifaceted nature, sarcopenic obesity is often undiagnosed and undertreated, posing a considerable challenge to healthcare systems worldwide. In this review, we explore the intricate interplay of factors contributing to the development and consequences of sarcopenic obesity and discuss newly proposed diagnostic guidelines aimed at improved screening. Enhancing awareness and understanding of sarcopenic obesity is imperative for addressing its growing prevalence and mitigating its adverse health effects.
全球预期寿命的增加导致肌肉减少症的诊断率随之上升。与此同时，肥胖的流行程度引发了一种名为“肌少症性肥胖”的复杂病症的出现。肌少症性肥胖的特征是肌肉质量和力量同时丧失，以及肥胖或体脂过多，它代表了一种令人担忧的健康状况。与普遍的假设相反，肌少症性肥胖并非老年人所特有，因为它也可能出现在肥胖和患有慢性疾病的个体以及那些经历快速体重减轻的人身上。脂肪堆积与肌肉消耗的这种并置体现了一种有害的组合，尤其是在健康成年人中。对肌少症性肥胖进行精确的定义，并了解不同身体成分如何影响功能参数、合并症和死亡率，对于全面理解这种病症的范围和重要性至关重要。尽管肌少症性肥胖具有多方面的性质，但它往往未被诊断和治疗不足，这给全球医疗保健系统带来了相当大的挑战。在这篇综述中，我们探讨了导致肌少症性肥胖发生和后果的各种因素之间的复杂相互作用，并讨论了旨在改进筛查的新提出的诊断指南。提高对肌少症性肥胖的认识和理解对于应对其日益增长的患病率并减轻其对健康的不利影响至关重要。
