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突触内用于增强和稳态的不同传递位点。

Distinct transmission sites within a synapse for strengthening and homeostasis.

作者信息

Yang Yue, Wong Man Ho, Huang Xiaojie, Chiu Delia N, Liu Yu-Zhang, Prabakaran Vishnu, Imran Amna, Panzeri Elisa, Chen Yixuan, Huguet Paloma, Kunisky Alexander, Ho Jonathan, Dong Yan, Carter Brett C, Xu Weifeng, Schlüter Oliver M

机构信息

Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.

European Neuroscience Institute Göttingen (ENI-G), ENI-G, a Joint Initiative of the University Medical Center Göttingen and the Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

出版信息

Sci Adv. 2025 Apr 11;11(15):eads5750. doi: 10.1126/sciadv.ads5750.

DOI:10.1126/sciadv.ads5750
PMID:40215296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11988405/
Abstract

At synapses, miniature synaptic transmission forms the basic unit of evoked transmission, thought to use one canonical transmission site. Two general types of synaptic plasticity, associative plasticity to change synaptic weights and homeostatic plasticity to maintain an excitatory balance, are so far thought to be expressed at individual canonical sites in principal neurons of the cortex. Here, we report two separate types of transmission sites, termed silenceable and idle-able, each participating distinctly in evoked or miniature transmission in the mouse visual cortex. Both sites operated with a postsynaptic binary mode with different unitary sizes and mechanisms. During postnatal development, silenceable sites were unsilenced by associative plasticity with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-receptor incorporation, increasing evoked transmission. Concurrently, miniature transmission remained constant, where AMPA-receptor state changes balanced unsilencing with increased idling at idle-able sites. Thus, individual cortical spine synapses mediated two parallel, interacting types of transmission, which predominantly contributed to either associative or homeostatic plasticity.

摘要

在突触处，微小突触传递形成了诱发传递的基本单位，一般认为其利用一个典型的传递位点。迄今为止，两种常见的突触可塑性，即用于改变突触权重的联合可塑性和用于维持兴奋性平衡的稳态可塑性，被认为是在皮层主神经元的单个典型位点表达的。在此，我们报告了两种不同类型的传递位点，分别称为可沉默位点和可闲置位点，它们在小鼠视觉皮层的诱发传递或微小传递中各自发挥着不同的作用。这两种位点均以具有不同单一大小和机制的突触后二元模式运作。在出生后发育过程中，可沉默位点通过与α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体结合的联合可塑性而被解除沉默，从而增加诱发传递。与此同时，微小传递保持不变，其中AMPA受体状态的变化使可沉默位点的解除沉默与可闲置位点增加的闲置状态相平衡。因此，单个皮层棘突触介导了两种平行且相互作用的传递类型，它们主要分别促成联合可塑性或稳态可塑性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/6d1b1ca4e62e/sciadv.ads5750-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/1aeab355764b/sciadv.ads5750-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/17f49b50e811/sciadv.ads5750-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/76f4b086a6f6/sciadv.ads5750-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/0192abaa7a41/sciadv.ads5750-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/3051f26b993f/sciadv.ads5750-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/876f9b627ef8/sciadv.ads5750-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/6a0675f3156d/sciadv.ads5750-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/69323a7e68d3/sciadv.ads5750-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/d2e85cdcc103/sciadv.ads5750-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/6d1b1ca4e62e/sciadv.ads5750-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/1aeab355764b/sciadv.ads5750-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/17f49b50e811/sciadv.ads5750-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/76f4b086a6f6/sciadv.ads5750-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/0192abaa7a41/sciadv.ads5750-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/3051f26b993f/sciadv.ads5750-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/876f9b627ef8/sciadv.ads5750-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/6a0675f3156d/sciadv.ads5750-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/69323a7e68d3/sciadv.ads5750-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/d2e85cdcc103/sciadv.ads5750-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8961/11988405/6d1b1ca4e62e/sciadv.ads5750-f10.jpg

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