乙二胺四乙酸（EDTA）和乙二醇双四乙酸（EGTA）对肾素分泌的影响。
The effects of EDTA and EGTA on renin secretion.
作者信息
Peart W S, Quesada T, Tenyi I
出版信息
Br J Pharmacol. 1977 Feb;59(2):247-52. doi: 10.1111/j.1476-5381.1977.tb07486.x.
Abstract
1 The effects of the disodium salt of ethylenediamine tetra-acetate (EDTA) and 1, 2, bis, 2 aminoethoxyethane-NNN'N'-tetra-acetic acid (EGTA) on renin secretion and vascular resistance were studied in the isolated perfused kidney of the rat. 2 Both substances produced a significant increase of renin release 3 In the absence of calcium and magnesium, EDTA still increased rein release and there was now a considerable increase of perfusion pressure. 4 The rise of pressure but not the rise of renin was inhibited by the removal of potassium from the perfusate when EDTA was administered in the absence of calcium. 5 Propranolol and phenoxybenzamine had no effect on the vasoconstrictor action of EDTA. 6 EGTA was less effective as a renin releaser than EDTA until magnesium was removed from the perfusate. Furter, it had only a small effect on perfusion pressure in contrast to EDTA.
摘要
- 研究了乙二胺四乙酸二钠盐（EDTA）和1,2-双（2-氨基乙氧基）乙烷-N,N,N',N'-四乙酸（EGTA）对大鼠离体灌注肾脏肾素分泌和血管阻力的影响。2. 两种物质均使肾素释放显著增加。3. 在无钙和镁的情况下，EDTA仍能增加肾素释放，且灌注压力有相当大的升高。4. 当在无钙情况下给予EDTA时，从灌注液中去除钾可抑制压力升高，但不能抑制肾素升高。5. 普萘洛尔和酚苄明对EDTA的血管收缩作用无影响。6. 在从灌注液中去除镁之前，EGTA作为肾素释放剂的效果不如EDTA。此外，与EDTA相比，它对灌注压力的影响很小。
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