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微小RNA分析揭示了高原心理性心血管疾病中心血管和心理健康的新型生物标志物。

MicroRNA profiling reveals novel biomarkers for cardiovascular and psychological health in plateau psycho CVD.

作者信息

Niu Xiu-Long, Liang Guo-Qing, Chen Shao-Bo, Li Yan, Wang Tao, Wang Xiaojing, Guo Qing, Gu Dong, Kang Le, Liu Changxing, Bi Xun, Cai Wei

机构信息

Department of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.

Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Tianjin, 300162, China.

出版信息

Sci Rep. 2025 Apr 11;15(1):12488. doi: 10.1038/s41598-025-97741-6.

DOI:10.1038/s41598-025-97741-6
PMID:40216962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11992083/
Abstract

This study aimed to explore the expression characteristics of miRNAs in cardiovascular diseases (CVD) and depression within a plateau environment, to better understand their potential role in Plateau Psycho-CVD. A prospective study design was employed to analyze circulating small RNAs from 20 subjects using high-throughput sequencing technology. Participants were divided into four groups (C, PPC, PP, PC) for comparative analysis. Differentially expressed miRNAs were selected for further functional enrichment analysis. The findings revealed that hsa-miR-1976 and hsa-miR-4685-3p were significantly upregulated in patients with Plateau Psycho-CVD and mental health issues. These miRNAs were closely associated with key pathways relevant to cardiovascular and mental health, including the PI3K-Akt and neurotrophin signaling pathways. Additionally, the downregulated miRNAs in the PPC group were linked to increased expression of AKT1 and STAT3, genes associated with bipolar disorder and inflammatory pathways, indicating a potential impact on neural function. This study identifies hsa-miR-1976 and hsa-miR-4685-3p as novel biomarkers for plateau stress dual heart disease, with AKT1 and STAT3 emerging as potential therapeutic targets. These insights pave the way for further research and clinical applications in related fields.

摘要

本研究旨在探讨高原环境中心血管疾病（CVD）和抑郁症中微小RNA（miRNA）的表达特征，以更好地了解它们在高原心脑血管精神疾病中的潜在作用。采用前瞻性研究设计，运用高通量测序技术分析20名受试者的循环小RNA。将参与者分为四组（C组、PPC组、PP组、PC组）进行比较分析。选择差异表达的miRNA进行进一步的功能富集分析。研究结果显示，hsa-miR-1976和hsa-miR-4685-3p在高原心脑血管精神疾病患者和有心理健康问题的患者中显著上调。这些miRNA与心血管和心理健康相关的关键通路密切相关，包括PI3K-Akt和神经营养因子信号通路。此外，PPC组中下调的miRNA与双相情感障碍和炎症通路相关基因AKT1和STAT3的表达增加有关，表明对神经功能有潜在影响。本研究确定hsa-miR-1976和hsa-miR-4685-3p为高原应激性双心疾病的新型生物标志物，AKT1和STAT3成为潜在的治疗靶点。这些见解为相关领域的进一步研究和临床应用铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/bf44dcdd6175/41598_2025_97741_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/2465b7029e92/41598_2025_97741_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/de515c580b0d/41598_2025_97741_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/e0188a121bbf/41598_2025_97741_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/cf8cbfb925b7/41598_2025_97741_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/bf44dcdd6175/41598_2025_97741_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/2465b7029e92/41598_2025_97741_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/1796e95f9ac3/41598_2025_97741_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/de515c580b0d/41598_2025_97741_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/e0188a121bbf/41598_2025_97741_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/cf8cbfb925b7/41598_2025_97741_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0780/11992083/bf44dcdd6175/41598_2025_97741_Fig6_HTML.jpg

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