Mao Fengjiao, Zhang Daya, Huang Xianfeng, Li Da, Chen Wenrui, Zeng Fan, Chen Chen, Huang Shimei, Lv Yanting, Huang Yuliang, Chen Runyu, Mo Ying, Nie Qiuli, Zhou Shuo, Zhang Xiaodong, Yao Qicen, Du Yiping, Ran Bo, Tan Yan, Liu Na, Xie Yunqian, Bai Feihu
The Second School of Clinical Medicine, Hainan Medical University, Haikou, 571199, China.
Department of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570216, China.
BMC Gastroenterol. 2025 Apr 11;25(1):244. doi: 10.1186/s12876-025-03810-5.
Cholecystectomy is one of the most common surgical procedures for the treatment of diseases associated with gallstones, and the incidence of post-cholecystectomy diarrhea (PCD) has attracted attention in recent years. The aim of this study was to assess the prevalence of PCD in patients with gallstones and to analyze the factors influencing it.
Between August 2022 and December 2024, there were 3385 cases of gallstones diagnosed by abdominal ultrasound or CT examination and laparoscopic cholecystectomy in tertiary hospitals in Hainan Province. All participants in this study were followed up by telephone within 1 year postoperatively and by telephone survey using a standardized questionnaire. The incidence of PCD was calculated, and the relevant components of the follow-up were analyzed by one-way and multifactorial logistic regression using SPSS 26.0 statistical software.
Four hundred seventy-nine patients (14.2%) developed PCD after undergoing laparoscopic cholecystectomy. Univariate analysis showed that age, BMI, dietary patterns, history of diabetes, alcohol consumption, gallstones and fatty liver disease were associated with the development of PCD ( P < 0.05). Binary logistic regression analysis showed that age (OR = 0.532, P = 0.010), BMI (OR = 40.615, P < 0.001), dietary patterns (OR = 0.635, P = 0.013), and history of diabetes (OR = 0.263, P < 0.001) were independent risk factors.
The incidence of PCD in Hainan Province is 14.2%. Over 50 years old, BMI, dietary pattern and history of diabetes were independent risk factors for the occurrence of PCD.
胆囊切除术是治疗胆结石相关疾病最常见的外科手术之一，近年来，胆囊切除术后腹泻（PCD）的发生率备受关注。本研究旨在评估胆结石患者中PCD的患病率，并分析影响其发生的因素。
2022年8月至2024年12月期间，海南省三级医院有3385例经腹部超声或CT检查诊断为胆结石并行腹腔镜胆囊切除术的患者。本研究所有参与者在术后1年内通过电话随访，并使用标准化问卷进行电话调查。计算PCD的发生率，并使用SPSS 26.0统计软件通过单因素和多因素逻辑回归分析随访的相关因素。
479例患者（14.2%）在接受腹腔镜胆囊切除术后发生了PCD。单因素分析显示，年龄、体重指数、饮食习惯、糖尿病史、饮酒、胆结石和脂肪肝疾病与PCD的发生有关（P<0.05）。二元逻辑回归分析显示，年龄（OR=0.532，P=0.010）、体重指数（OR=40.615，P<0.001）、饮食习惯（OR=0.635，P=0.013）和糖尿病史（OR=0.263，P<0.001）是独立危险因素。
海南省PCD的发生率为14.2%。50岁以上、体重指数、饮食习惯和糖尿病史是PCD发生的独立危险因素。
