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对结核病相关肺功能损害中肺量计解读的批判性分析:对一项中国研究的评论

Critical analysis of spirometry interpretation in tuberculosis-related lung function impairment: a commentary on a Chinese study.

作者信息

Barkous Balsam, Boubakri Saba, Saad Helmi Ben

机构信息

Laboratory of physiology and functional explorations, Farhat Hached Hospital, Sousse, Tunisia.

Farhat HACHED Hospital, Heart Failure (LR12SP09) Research Laboratory, University of Sousse, Sousse, Tunisia.

出版信息

BMC Pulm Med. 2025 Apr 11;25(1):171. doi: 10.1186/s12890-025-03642-9.

Abstract

We commend Zhao et al. for their insightful paper titled "Analysis of clinical characteristics of different types of lung function impairment in TDL patients," which compares the severity of lung function patterns, including restrictive and obstructive ventilatory patterns, with the clinical characteristics of tuberculosis-destroyed lung patients. This study is significant for healthcare providers managing long-term tuberculosis cases, especially with the rise of multidrug-resistant strains. By analyzing spirometry data, the study offers valuable insights into the correlation between lung function patterns and tuberculosis-destroyed lung, laying a foundation for future research aimed at developing targeted therapies. However, the study's definitions for normal spirometry patterns, restrictive and obstructive ventilatory patterns, as well as the severity grading of lung function patterns, diverge from established guidelines by the American Thoracic Society and European Respiratory Society. These discrepancies, particularly the use of post-bronchodilator values and the exclusion of recognized patterns like 'isolated low forced expiratory volume in one second' and 'dysanapsis,' necessitate further discussion. Adopting standardized spirometry interpretations, as recommended by international guidelines, will enhance the study's conclusions and contribute to improved clinical practice and patient care.

摘要

我们赞扬Zhao等人发表的题为《TDL患者不同类型肺功能损害的临床特征分析》的见解深刻的论文。该论文比较了包括限制性和阻塞性通气模式在内的肺功能模式的严重程度与肺结核毁损肺患者的临床特征。这项研究对于管理长期结核病病例的医疗服务提供者具有重要意义,尤其是在耐多药菌株不断增加的情况下。通过分析肺量计数据,该研究为肺功能模式与肺结核毁损肺之间的相关性提供了有价值的见解,为未来旨在开发靶向治疗的研究奠定了基础。然而,该研究对正常肺量计模式、限制性和阻塞性通气模式的定义,以及肺功能模式的严重程度分级,与美国胸科学会和欧洲呼吸学会既定的指南有所不同。这些差异,特别是支气管扩张剂后值的使用以及对“单纯一秒用力呼气量降低”和“失协调”等公认模式的排除,需要进一步讨论。采用国际指南推荐的标准化肺量计解释,将加强该研究的结论,并有助于改善临床实践和患者护理。

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