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中国抗癫痫协会癫痫外科专业委员会关于小儿癫痫外科的共识:一项调查

Consensus on pediatric epilepsy surgery for young children: an investigation by the China Association Against Epilepsy task force on epilepsy surgery.

作者信息

Cai Lixin, Zhang Kai, Zhou Wenjing, Shao Xiaoqiu, Guan Yuguang, Yu Tao, Wu Ye, Chen Shuhua, Zhao Rui, Liang Shuli, Wu Xun, Luan Guoming, Jiang Yuwu, Zhang Jianguo, Liu Xiaoyan

机构信息

Pediatric Epilepsy Center, Peking University First Hospital, Beijing, 100000, China.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100000, China.

出版信息

Acta Epileptol. 2023 Aug 14;5(1):20. doi: 10.1186/s42494-023-00130-7.

Abstract

Researchers have widely acknowledged the therapeutic value of epilepsy surgery for drug-resistant epilepsy. Nonetheless, there is a substantial gap in the surgical treatment for appropriate candidates owing to several factors, particularly in the population of young children. To standardize the protocols of preoperative evaluation and surgery of young children for epilepsy surgery, the China Association Against Epilepsy has appointed an expert task force to standardize the protocols of preoperative evaluation and surgery in pediatric epilepsy patients. It adopted the modified Delphi method and performed two rounds of surveys through an anonymous inquiry among 75 experts from four subgroups including pediatric neurologists, epileptologists, pediatric epilepsy surgeons, and functional neurosurgeons. The survey contents contained: (1) the participants, comprising children aged ≤ 6 years; (2) adopted DRE definition proposed by the International League Against Epilepsy in 2010; and (3) investigated epilepsy surgery, principally referring to curative epilepsy surgeries. The neuromodulation therapies were excluded because of the differences in treatment mechanisms from the above-mentioned surgeries. According to the Delphi process, a consensus was achieved for most aspects by incorporating two rounds of surveys including preoperative assessment, surgical strategies and techniques, and perioperative and long-term postoperative management, despite controversial opinions on certain items. We hope the results of this consensus will improve the level of surgical treatment and management of intractable epilepsy in young children.

摘要

研究人员已广泛认可癫痫手术对药物难治性癫痫的治疗价值。尽管如此,由于多种因素,尤其是在幼儿群体中,适合手术的患者在手术治疗方面仍存在很大差距。为规范小儿癫痫手术的术前评估和手术方案,中国抗癫痫协会已指定一个专家工作组来规范小儿癫痫患者的术前评估和手术方案。该工作组采用改良德尔菲法,通过对小儿神经科医生、癫痫专家、小儿癫痫外科医生和功能神经外科医生四个亚组的75名专家进行匿名调查,进行了两轮调查。调查内容包括:(1)参与者,为年龄≤6岁的儿童;(2)采用国际抗癫痫联盟2010年提出的药物难治性癫痫(DRE)定义;(3)调查的癫痫手术,主要指根治性癫痫手术。由于神经调节疗法与上述手术的治疗机制不同,故将其排除。根据德尔菲流程,尽管在某些项目上存在争议性意见,但通过两轮调查,在术前评估、手术策略和技术以及围手术期和术后长期管理等大多数方面达成了共识。我们希望这一共识的结果将提高幼儿难治性癫痫的手术治疗和管理水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfcd/11960312/7039d9aff0f6/42494_2023_130_Fig1_HTML.jpg

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