预测迷走神经刺激治疗药物难治性癫痫疗效的电生理指标研究进展
Research progress on the electrophysiological indicators to predict the efficacy of vagus nerve stimulation for drug-refractory epilepsy.
作者信息
Li Guangli, Li Zhenguang, Liu Yingting
机构信息
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, China.
Epilepsy Center of Brain Hospital of Hunan Province, Changsha, 410007, Hunan Province, China.
出版信息
Acta Epileptol. 2024 Mar 1;6(1):7. doi: 10.1186/s42494-023-00147-y.
Abstract
Vagus nerve stimulation (VNS) is an important treatment option for drug-refractory epilepsy (DRE), with well-established efficacy and safety in clinical practice for more than 20 years. However, it is very difficult to find the optimal electrophysiological indicators for the effectiveness of VNS on DRE because the mechanism of action is unknown. In this review, we provide an update of the potential applications of VNS outcomes in patients with drug-resistant epilepsy. Electroencephalographic (EEG) activity, event-related potentials, EEG synchronization levels, magnetoencephalographic, laryngeal muscle evoked potentials, and heart rate variability are potential biomarkers for VNS outcomes in people with DRE.
摘要
迷走神经刺激（VNS）是药物难治性癫痫（DRE）的一种重要治疗选择，在临床实践中已证实其有效性和安全性超过20年。然而，由于其作用机制尚不清楚，很难找到评估VNS治疗DRE有效性的最佳电生理指标。在本综述中，我们更新了VNS治疗结果在耐药性癫痫患者中的潜在应用情况。脑电图（EEG）活动、事件相关电位、EEG同步水平、脑磁图、喉肌诱发电位和心率变异性是DRE患者VNS治疗结果的潜在生物标志物。
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本文引用的文献
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Laryngeal Muscle-Evoked Potential Recording as an Indicator of Vagal Nerve Fiber Activation.喉肌诱发电位记录作为迷走神经纤维激活的指标。
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Vagus Nerve Stimulation Elicits Sleep EEG Desynchronization and Network Changes in Responder Patients in Epilepsy.迷走神经刺激可引起癫痫应答患者睡眠脑电图去同步化和网络变化。
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Alteration in brain connectivity in patients with Dravet syndrome after vagus nerve stimulation (VNS): exploration of its effectiveness using graph theory analysis with electroencephalography.迷走神经刺激（VNS）后Dravet综合征患者脑连接性的改变：使用脑电图的图论分析探索其有效性
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Neurophysiological investigations of drug resistant epilepsy patients treated with vagus nerve stimulation to differentiate responders from non-responders.对接受迷走神经刺激治疗的耐药性癫痫患者进行神经生理学研究，以区分反应者和无反应者。
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The Immediate Effects of Vagus Nerve Stimulation in Intractable Epilepsy: An Intra-operative Electrocorticographic Analysis.难治性癫痫患者迷走神经刺激的即刻效应：一项术中脑电皮质电图分析。
Neurol Med Chir (Tokyo). 2020 May 15;60(5):244-251. doi: 10.2176/nmc.oa.2019-0221. Epub 2020 Apr 15.
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Neuroimage Clin. 2020;26:102205. doi: 10.1016/j.nicl.2020.102205. Epub 2020 Feb 4.
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Connectomic Profiling Identifies Responders to Vagus Nerve Stimulation.连接组学分析鉴定出迷走神经刺激的应答者。
Ann Neurol. 2019 Nov;86(5):743-753. doi: 10.1002/ana.25574. Epub 2019 Aug 27.
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