Badea Ionuț-Andrei, Bojincă Mihai, Bojincă Violeta, Milicescu Mihaela, Ghițescu Gabriel, Casandra Negoiță, Ilina Andreea-Ruxandra, Vulcan Mădălina-Ștefania, Aramă Ștefan-Sorin
Department of Rheumatology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Internal Medicine, Clinical Hospital Dr. I. Cantacuzino, 030167 Bucharest, Romania.
J Clin Med. 2025 Mar 30;14(7):2372. doi: 10.3390/jcm14072372.
: Bone mineral density (BMD) variation under vitamin D supplementation, determined using dual-energy X-ray absorptiometry (DXA), is the gold standard and the main tool used in most studies in this domain. However, the scientific literature is lacking with regard to the usefulness of REMS in BMD follow-up, especially the importance of the fragility score (FS). The main objective of this study was to determine whether FS follow-up is relevant in a group of patients with axial spondyloarthritis and whether REMS could have clinical applicability. : Patients with a certain diagnosis of axial spondyloarthritis (AxSpA) were recruited from two medical healthcare centers and were scanned using Radiofrequency Echographic Multi-Spectrometry in order to obtain their fragility score (FS), an objective measurement of bone quality. The main group was randomized into a vitamin D supplementation branch and a non-supplementation branch and followed up every 6 months for 18 months in total. Comparisons between the branches were made using MiniTab v.20 statistical software. : Lower FS values were obtained in patients who initially had high scores, suggesting a positive impact of vitamin D on bone quality ( = 0.008). Muscle strength was evaluated through a visual analogue scale (VAS), with improvements being seen in the supplementation branch ( < 0.005). Furthermore, although some patients had experienced falls in previous years, during the study period, no new events were recorded in either group. : The FS is a reliable tool for evaluating bone architecture and is useful in everyday practice for the management of patients taking vitamin D supplements.
：使用双能X线吸收法（DXA）测定的维生素D补充治疗下的骨密度（BMD）变化是该领域大多数研究中使用的金标准和主要工具。然而，关于REMS在BMD随访中的有用性，特别是脆性评分（FS）的重要性，科学文献中尚缺乏相关内容。本研究的主要目的是确定FS随访在一组轴向脊柱关节炎患者中是否相关，以及REMS是否具有临床适用性。：从两个医疗保健中心招募确诊为轴向脊柱关节炎（AxSpA）的患者，并使用射频超声多光谱法进行扫描，以获得其脆性评分（FS），这是一种对骨质的客观测量。主要组被随机分为维生素D补充组和非补充组，总共随访18个月，每6个月随访一次。使用MiniTab v.20统计软件对两组进行比较。：初始评分高的患者获得了较低的FS值，表明维生素D对骨质有积极影响（P = 0.008）。通过视觉模拟量表（VAS）评估肌肉力量，补充组有改善（P < 0.005）。此外，尽管一些患者在过去几年中曾跌倒，但在研究期间，两组均未记录到新的跌倒事件。：FS是评估骨骼结构的可靠工具，在日常实践中对服用维生素D补充剂的患者管理很有用。
