Deng Sisi, He Yi, Nian Xinying, Sun Erwei, Li Li
Department of Nursing, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Department of Rheumatology and Immunology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Int J Nurs Sci. 2019 Dec 12;7(1):54-59. doi: 10.1016/j.ijnss.2019.12.005. eCollection 2020 Jan 10.
To explore the relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis (axSpA).
A convenience sample of 131 newly diagnosed axSpA patients and 60 healthy controls was recruited from July 2016 to December 2018. Serum 25-hydroxyvitamin D [25(OH)D] was measured to assess vitamin D levels. Disease activity was assessed by objective indicators [Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the Bath Ankylosing Spondylitis Metrology Index (BASMI)], patient-reported questionnaires [the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and the Bath Ankylosing Spondylitis Functional Index (BASFI)]. Pain intensity and interference were also assessed.
Vitamin D insufficiency [serum 25(OH) D levels<50 nmol/L]was found in 46 (35.1%) and 25 (43.3%) of the axSpA patients and the healthy controls, respectively. Female patients had higher risk (:4.928; 95% CI: 1.921-12.642) for vitamin D insufficiency than male patients. Vitamin D was positively correlated with CRP, ESR level, the BASFI, and the BASMI. Logistic regression showed that vitamin D levels were not associated with pain, or disease activity in the newly diagnosed axSpA patients. Gender was the only predictive variable for vitamin D levels.
Vitamin D insufficiency was prevalent in both newly diagnosed axSpA patients and healthy controls. There was no association between vitamin D and pain and disease activity in the newly diagnosed axSpA patients. Monitoring vitamin D levels is important and early intervention for vitamin D insufficiency is needed, especially in female patients.
探讨新诊断的中轴型脊柱关节炎（axSpA）患者维生素D水平与疼痛及疾病活动度之间的关系。
2016年7月至2018年12月，选取131例新诊断的axSpA患者和60例健康对照作为便利样本。检测血清25-羟基维生素D[25(OH)D]以评估维生素D水平。通过客观指标[红细胞沉降率（ESR）、C反应蛋白（CRP）、巴斯强直性脊柱炎测量指数（BASMI）]、患者报告问卷[巴斯强直性脊柱炎疾病活动指数（BASDAI）和巴斯强直性脊柱炎功能指数（BASFI）]评估疾病活动度。同时评估疼痛强度和干扰情况。
axSpA患者和健康对照中，维生素D不足[血清25(OH)D水平<50 nmol/L]的发生率分别为46例（35.1%）和25例（43.3%）。女性患者维生素D不足的风险高于男性患者（比值比：4.928；95%置信区间：1.921 - 12.642）。维生素D与CRP、ESR水平、BASFI和BASMI呈正相关。逻辑回归显示，新诊断的axSpA患者中维生素D水平与疼痛或疾病活动度无关。性别是维生素D水平的唯一预测变量。
新诊断的axSpA患者和健康对照中维生素D不足均较为普遍。新诊断的axSpA患者中维生素D与疼痛及疾病活动度无关联。监测维生素D水平很重要，对于维生素D不足需要进行早期干预，尤其是在女性患者中。
