Cho In-Jeong, Lee Sang-Eun, Pyun Wook-Bum
Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea.
J Clin Med. 2025 Mar 31;14(7):2399. doi: 10.3390/jcm14072399.
Left ventricular hypertrophy (LVH) is a key predictor of cardiovascular disease. This study aimed to investigate the correlation between LVH and regional adipose tissue deposits, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and epicardial adipose tissue (EAT), and sex-related differences in these correlations. A total of 416 individuals (median age 66 years, range 20-95), without structural heart disease or a history of hypertension and coronary artery disease, underwent echocardiography and abdominal computed tomography. Statistical analyses included logistic and linear regression to assess the associations between adipose tissue measures and LVH. LVH was associated with older age, higher systolic blood pressure, and increased EAT thickness. EAT thickness was independently associated with LVH in women (OR 1.21, 95% CI 1.03-1.44, = 0.024) but not in men. Scatter plot analysis revealed a positive correlation between EAT and left ventricular mass index (LVMI) in women (r = 0.366, < 0.001) and a negative correlation in men (r = -0.153, = 0.038). VAT and SAT showed no significant associations with LVMI or LVH in either sex. These findings suggest that EAT, but not VAT or SAT, is linked to cardiac remodeling in a sex-specific manner.
左心室肥厚（LVH）是心血管疾病的关键预测指标。本研究旨在调查LVH与局部脂肪组织沉积之间的相关性，包括内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和心外膜脂肪组织（EAT），以及这些相关性中的性别差异。共有416名个体（年龄中位数66岁，范围20 - 95岁），无结构性心脏病或高血压及冠状动脉疾病病史，接受了超声心动图检查和腹部计算机断层扫描。统计分析包括逻辑回归和线性回归，以评估脂肪组织测量值与LVH之间的关联。LVH与年龄较大、收缩压较高以及EAT厚度增加有关。EAT厚度在女性中与LVH独立相关（比值比1.21，95%置信区间1.03 - 1.44，P = 0.024），而在男性中则不然。散点图分析显示，女性中EAT与左心室质量指数（LVMI）呈正相关（r = 0.366，P < 0.001），男性中呈负相关（r = -0.153，P = 0.038）。VAT和SAT在两性中与LVMI或LVH均无显著关联。这些发现表明，EAT而非VAT或SAT以性别特异性方式与心脏重塑相关。
