Rîșniță Sandra, Išerić Emina, Zijlstra Maureen N, Stock Ann-Kathrin, Verster Joris C
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The Netherlands.
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany.
J Clin Med. 2025 Apr 2;14(7):2428. doi: 10.3390/jcm14072428.
: Tolerance to the acute effects of alcohol, i.e., feeling less intoxicated after consuming the same amount of alcohol, has been reported for individuals who regularly consume alcohol. In this study, it was investigated whether such tolerance also exists for experiencing the alcohol hangover. : Data from five studies that assessed hangover frequency and hangover severity were combined (n = 924). Partial correlations were computed between hangover frequency and hangover severity, with age, sex, and weekly alcohol consumption as possible confounders. : A significant and positive correlation was found between hangover frequency and hangover severity (r = 0.692, < 0.001). After correcting for sex, age, and weekly alcohol consumption, the partial correlation remained significant (r = 0.526, < 0.001). : The observed positive association between hangover frequency and hangover severity suggests a reverse tolerance: if hangovers are experienced more frequently, they are more severe.
据报道，经常饮酒的人对酒精的急性作用会产生耐受性，即饮用相同量的酒精后感觉醉酒程度减轻。在本研究中，探讨了在经历宿醉方面是否也存在这种耐受性。
对五项评估宿醉频率和宿醉严重程度的研究数据进行了合并（n = 924）。计算了宿醉频率与宿醉严重程度之间的偏相关性，并将年龄、性别和每周饮酒量作为可能的混杂因素。
发现宿醉频率与宿醉严重程度之间存在显著正相关（r = 0.692，<0.001）。在对性别、年龄和每周饮酒量进行校正后，偏相关性仍然显著（r = 0.526，<0.001）。
如果宿醉更频繁地发生，那么宿醉会更严重。
