• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Use of oxygenated sterols to probe the regulation of 3-hydroxy-3-methylglutaryl-CoA reductase and sterologenesis.

作者信息

Taylor F R, Kandutsch A A

出版信息

Methods Enzymol. 1985;110:9-19. doi: 10.1016/s0076-6879(85)10055-8.

DOI:10.1016/s0076-6879(85)10055-8
PMID:4021822
Abstract
摘要

相似文献

1
Use of oxygenated sterols to probe the regulation of 3-hydroxy-3-methylglutaryl-CoA reductase and sterologenesis.利用氧化甾醇探究3-羟基-3-甲基戊二酰辅酶A还原酶的调控及甾醇生成。
Methods Enzymol. 1985;110:9-19. doi: 10.1016/s0076-6879(85)10055-8.
2
Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor.氧化甾醇在调节3-羟基-3-甲基戊二酰辅酶A还原酶降解、抑制3-羟基-3-甲基戊二酰辅酶A合酶以及与氧化甾醇受体亲和力方面的效力之间的相关性。
Biochem Biophys Res Commun. 1992 Jul 15;186(1):182-9. doi: 10.1016/s0006-291x(05)80791-0.
3
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的可逆磷酸化调节：低密度脂蛋白、固醇和甲羟戊酸内酯对酶活性的调节
Arch Biochem Biophys. 1986 Jan;244(1):310-22. doi: 10.1016/0003-9861(86)90120-7.
4
Growth-rate-related and hydroxysterol-induced changes in membrane fluidity of cultured hepatoma cells: correlation with 3-hydroxy-3-methyl glutaryl CoA reductase activity.培养的肝癌细胞中与生长速率相关及羟类固醇诱导的膜流动性变化：与3-羟基-3-甲基戊二酰辅酶A还原酶活性的相关性
Biochem Biophys Res Commun. 1984 Apr 16;120(1):192-8. doi: 10.1016/0006-291x(84)91432-3.
5
Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.甾醇合成抑制剂。4,4-二甲基-15-氧化甾醇在培养的哺乳动物细胞中对甾醇合成及3-羟基-3-甲基戊二酰辅酶A还原酶活性的化学合成、性质及作用。
Chem Phys Lipids. 1988 Jul;47(3):187-207. doi: 10.1016/0009-3084(88)90012-6.
6
Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes.25-羟基胆固醇对大鼠体内、灌注肝脏及肝细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的影响。
J Biol Chem. 1978 Jun 25;253(12):4159-64.
7
Regulation of 3-hydroxy-3-methylglutaryl CoA reductase by analogs of cholesterol and bile acids in cultured intestinal mucosa.胆固醇和胆汁酸类似物对培养的肠黏膜中3-羟基-3-甲基戊二酰辅酶A还原酶的调节作用
Lipids. 1981 May;16(5):397-400. doi: 10.1007/BF02534972.
8
Inhibitors of sterol biosynthesis. Synthesis and activities of ring C oxygenated sterols.固醇生物合成抑制剂。C环氧化固醇的合成与活性。
Chem Phys Lipids. 1988 Feb;46(2):147-54. doi: 10.1016/0009-3084(88)90125-9.
9
Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.氧化甾醇与胞质结合蛋白的结合及对羟甲基戊二酰辅酶A还原酶抑制作用的效力之间的相关性。
J Biol Chem. 1984 Oct 25;259(20):12382-7.
10
Effect of oxygenated sterols on 3-hydroxy-3-methylglutaryl coenzyme A reductase and DNA synthesis in phytohemagglutinin-stimulated human lymphocytes.氧化甾醇对植物血凝素刺激的人淋巴细胞中3-羟基-3-甲基戊二酰辅酶A还原酶及DNA合成的影响。
Biochem Biophys Res Commun. 1978 Nov 29;85(2):691-700. doi: 10.1016/0006-291x(78)91217-2.

引用本文的文献

1
Structure-Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (OSBP) and OSBP-Related Protein 4.配体与氧化固醇结合蛋白（OSBP）及其相关蛋白 4 结合的结构-活性关系。
J Med Chem. 2023 Mar 23;66(6):3866-3875. doi: 10.1021/acs.jmedchem.2c01025. Epub 2023 Mar 14.
2
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.OSBP相关蛋白2是脂滴上的一种固醇受体，可调节中性脂质的代谢。
J Lipid Res. 2009 Jul;50(7):1305-15. doi: 10.1194/jlr.M800661-JLR200. Epub 2009 Feb 17.
3
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
哺乳动物的氧化甾醇结合蛋白相关蛋白（ORPs）在一个进化保守的口袋中结合25-羟基胆固醇。
Biochem J. 2007 Aug 1;405(3):473-80. doi: 10.1042/BJ20070176.
4
Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain.在中国仓鼠卵巢细胞中，过表达氧化甾醇结合蛋白时胆固醇和胆固醇酯合成的调节改变依赖于普列克底物蛋白同源结构域。
Biochem J. 1997 Aug 15;326 ( Pt 1)(Pt 1):205-13. doi: 10.1042/bj3260205.