Jiang Xiaoxin, Ren Jingyi, Yu Gejun, Wu Wentao, Chen Mengyuan, Zhao Yun, He Canxia
School of Public Health, Health Science Center, Ningbo University, Ningbo 315211, China.
Nutrients. 2025 Mar 28;17(7):1174. doi: 10.3390/nu17071174.
Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing a significant global health burden. Recent studies highlight the critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC's pathogenesis. The relationship between BAs and gut microbiota is bidirectional: microbiota influence BA composition, while BAs regulate microbiota diversity and activity through receptors like Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). Targeting bile-acid metabolism to reshape gut microbiota presents a promising therapeutic strategy for UC. This review examines the classification and synthesis of BAs, their interactions with gut microbiota, and the potential of nutritional and microbial interventions. By focusing on these therapies, we aim to offer innovative approaches for effective UC management.
溃疡性结肠炎（UC）是一种影响结肠直肠的慢性炎症性疾病，给全球健康带来了重大负担。最近的研究强调了肠道微生物群及其代谢产物，特别是胆汁酸（BAs）在UC发病机制中的关键作用。BAs与肠道微生物群之间的关系是双向的：微生物群影响BA的组成，而BAs通过法尼醇X受体（FXR）和武田G蛋白偶联受体5（TGR5）等受体调节微生物群的多样性和活性。针对胆汁酸代谢来重塑肠道微生物群为UC提供了一种有前景的治疗策略。本综述探讨了BAs的分类和合成、它们与肠道微生物群的相互作用以及营养和微生物干预的潜力。通过关注这些疗法，我们旨在为UC的有效管理提供创新方法。
