Jiang Kexin, Bai Yinuo, Hou Ruyan, Chen Guijie, Liu Lingyi, Ciftci Ozan N, Farag Mohamed A, Liu Lianliang
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang, China.
State Key Laboratory of Tea Plant Biology and Utilization, Key Laboratory of Food Nutrition and Safety, School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei 230036, China.
Food Chem. 2025 Apr 30;472:142932. doi: 10.1016/j.foodchem.2025.142932. Epub 2025 Jan 20.
Dietary polyphenols represent a diverse group of plant-derived compounds known for their extensive biological activities, offering significant promise in the prevention and treatment of various chronic illnesses. Despite their potential, advancements in their research have been curtailed by challenges in structural analysis and limitations in existing research models. This review marks a pioneering exploration into how bile acids, gut microbiota, and the gut-brain axis serve as conduits through which dietary polyphenols can exert therapeutic effects on Inflammatory Bowel Disease (IBD). This review enriches understanding of their biological functions and addresses common obstacles in the study of natural polyphenols. It provides a comprehensive examination of the role of dietary polyphenols in modulating bile acid metabolism and mitigating IBD, covering aspects such as polyphenols, bile acid metabolism, oxidative stress, inflammation, and the nervous system. This work opens new vistas in appreciating the full spectrum of polyphenol benefits, laying the groundwork for future explorations in this domain.
膳食多酚是一类多样的植物源化合物，以其广泛的生物活性而闻名，在预防和治疗各种慢性疾病方面具有巨大潜力。尽管它们具有潜力，但结构分析方面的挑战和现有研究模型的局限性限制了它们的研究进展。本综述首次探索了胆汁酸、肠道微生物群和肠-脑轴如何作为膳食多酚对炎症性肠病（IBD）发挥治疗作用的途径。本综述丰富了对其生物学功能的理解，并解决了天然多酚研究中的常见障碍。它全面考察了膳食多酚在调节胆汁酸代谢和减轻IBD方面的作用，涵盖了多酚、胆汁酸代谢、氧化应激、炎症和神经系统等方面。这项工作为全面认识多酚的益处开辟了新视野，为该领域的未来探索奠定了基础。
