Gerić Marko, Nanić Lucia, Micek Vedran, Novak Jovanović Ivana, Gajski Goran, Rašić Dubravka, Orct Tatjana, Ljubojević Marija, Karaica Dean, Jurasović Jasna, Vrhovac Madunić Ivana, Peraica Maja, Sabolić Ivan, de Andrade Vanessa Moraes, Breljak Davorka, Rubelj Ivica
Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.
Laboratory for Molecular and Cellular Biology, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Nutrients. 2025 Mar 28;17(7):1187. doi: 10.3390/nu17071187.
Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats.
The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys.
Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment.
Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.
鉴于人口老龄化带来的挑战日益增加，尤其是在西方国家，我们旨在研究白藜芦醇和褪黑素对衰老大鼠的潜在老年保护作用。
从3月龄开始用这两种化合物对动物进行治疗，持续至1岁或2岁。我们采用多生物标志物方法，评估了它们尿液、肝脏和肾脏中的DNA损伤、端粒长度和氧化状态。
尽管采用了这种实验方法，但我们的结果并未提供在所评估器官中存在老年保护作用的确凿证据。然而，我们观察到了治疗反应中的性别差异。
鉴于这两种化合物的高效能，有必要进一步研究，以探索将它们纳入日常生活作为减轻衰老相关影响的一种策略。
