Can Ismail, Akyurek Fatma Tuncez
Konya Numune Hastanesi, Konya, Turkey.
Selçuk Üniversitesi Tıp Fakültesi Hastanesi, Konya, Turkey.
Arch Dermatol Res. 2025 Apr 12;317(1):707. doi: 10.1007/s00403-025-04225-8.
The main factor in the development of basal cell carcinoma (BCC) is UV (ultraviolet) exposure. In most cases of BCC there is upregulation of the 'Sonic Hedgehog' (SHH) pathway components. Some recent studies have shown that overactivity of the SHH pathway leads to an increase in the number of sebocytes in the skin. Sex differences in tumor formation suggest a possible role of sex hormones in the development of skin cancers.
We aimed to evaluate the 2D:4D ratio and its relationship with skin sebum level in patients with BCC.
Finger length measurements were made using digital calipers. Skin sebum levels were measured using sebumeter.
The study included 64 patients with BCC(mean age 67) and 64 healthy subjects(mean age 71) aged 37-92 years. T score (average of sebum levels on forehead, nose and chin) and total sebum score (TSS) were higher in patients with BCC. U score (average of sebum levels of right and left cheeks) was similar in patients and control group. In male subjects, T score, U score and TSS were significantly higher in the patient group. In female subjects, there was no significant difference between the patient and control groups in T score, U score and TSS. The 2D:4D ratio in both hands was similar in the patient and control groups. When evaluated according to the localization of the lesions, the T score and the TSS were found to be higher in male subjects with BCC lesions in the T region than in the control group. In the female patient group, the T score was found to be significantly higher than in the control group.
There was no correlation between BCC and 2D:4D ratio. We found that skin sebum levels were higher in male patients with BCC compared to the control group. Defining the relationship between BCC and sebum levels may play an important role in the evaluation of the occurrence and prognosis of the disease.
基底细胞癌（BCC）发生发展的主要因素是紫外线（UV）暴露。在大多数BCC病例中，“音猬因子”（SHH）信号通路成分上调。最近一些研究表明，SHH信号通路过度活跃会导致皮肤中皮脂腺细胞数量增加。肿瘤形成中的性别差异提示性激素在皮肤癌发生发展中可能发挥作用。
我们旨在评估BCC患者的2D:4D比值及其与皮肤皮脂水平的关系。
使用数字卡尺测量手指长度。使用皮脂仪测量皮肤皮脂水平。
该研究纳入了64例BCC患者（平均年龄67岁）和64名健康受试者（平均年龄71岁），年龄在37至92岁之间。BCC患者的T评分（前额、鼻子和下巴皮脂水平的平均值）和总皮脂评分（TSS）更高。U评分（左右脸颊皮脂水平的平均值）在患者组和对照组中相似。在男性受试者中，患者组的T评分、U评分和TSS显著更高。在女性受试者中，患者组和对照组在T评分、U评分和TSS方面无显著差异。患者组和对照组双手的2D:4D比值相似。根据病变部位评估时，T区域有BCC病变的男性受试者的T评分和TSS高于对照组。在女性患者组中，发现T评分显著高于对照组。
BCC与2D:4D比值之间无相关性。我们发现，与对照组相比，BCC男性患者的皮肤皮脂水平更高。明确BCC与皮脂水平之间的关系可能在该疾病的发生及预后评估中发挥重要作用。
