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IdeZ protease does not prevent convertase stabilization by C3 nephritic factors in C3 glomerulopathy.

作者信息

Stevens Kes H, Baas Laura M, van de Kar Nicole C A J, van den Heuvel Lambertus P W J, Michels Marloes A H M

机构信息

Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.

Department of Genetics, Translational Metabolic Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands.

出版信息

Nephrol Dial Transplant. 2025 Aug 1;40(8):1628-1631. doi: 10.1093/ndt/gfaf065.

DOI:10.1093/ndt/gfaf065
PMID:40221135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12315799/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfbb/12315799/773bd27136a1/gfaf065fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfbb/12315799/773bd27136a1/gfaf065fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfbb/12315799/773bd27136a1/gfaf065fig1.jpg

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本文引用的文献

1
Complement inhibitors for kidney disease.补体抑制剂治疗肾病。
Nephrol Dial Transplant. 2023 Nov 8;38(Supplement_2):ii29-ii39. doi: 10.1093/ndt/gfad079.
2
Challenges in diagnostic testing of nephritic factors.肾病因子诊断检测的挑战。
Front Immunol. 2022 Nov 14;13:1036136. doi: 10.3389/fimmu.2022.1036136. eCollection 2022.
3
Endopeptidase Cleavage of Anti-Glomerular Basement Membrane Antibodies in Severe Kidney Disease: An Open-Label Phase 2a Study.严重肾脏疾病中抗肾小球基底膜抗体的内肽酶切割：一项开放标签 2a 期研究。
J Am Soc Nephrol. 2022 Apr;33(4):829-838. doi: 10.1681/ASN.2021111460. Epub 2022 Mar 8.
4
Imlifidase for the treatment of anti-HLA antibody-mediated processes in kidney transplantation.伊米利法酶用于治疗肾移植中抗人白细胞抗原抗体介导的过程。
Am J Transplant. 2022 Mar;22(3):691-697. doi: 10.1111/ajt.16828. Epub 2021 Sep 13.
5
Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes).交叉配型阳性、高度致敏的肾移植受者中伊米利昔酶脱敏：一项国际 2 期试验（Highdes）的结果。
Transplantation. 2021 Aug 1;105(8):1808-1817. doi: 10.1097/TP.0000000000003496.
6
Administration of immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) for persistent anti-ADAMTS13 antibodies in patients with thrombotic thrombocytopenic purpura in clinical remission.给予化脓性链球菌免疫球蛋白G降解酶（IdeS）用于临床缓解期血栓性血小板减少性紫癜患者中持续存在的抗ADAMTS13抗体。
Br J Haematol. 2019 Jul;186(1):137-140. doi: 10.1111/bjh.15706. Epub 2018 Nov 29.
7
Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN.阐明 C3G 和 IC-MPGN 中肾炎因子导致补体失调的分子机制。
Front Immunol. 2018 Oct 15;9:2329. doi: 10.3389/fimmu.2018.02329. eCollection 2018.
8
Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies.利妥昔单抗治疗膜增生性肾小球肾炎和C3肾小球病
Biomed Res Int. 2017;2017:2180508. doi: 10.1155/2017/2180508. Epub 2017 May 9.
9
Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation.针对C3肾炎因子的敏感且特异的检测方法阐明了补体失调的潜在机制。
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10
IdeS: a bacterial proteolytic enzyme with therapeutic potential.IdeS：一种具有治疗潜力的细菌蛋白水解酶。
PLoS One. 2008 Feb 27;3(2):e1692. doi: 10.1371/journal.pone.0001692.