Evaluation on the clinical findings and allergological factors of local allergic conjunctivitis and non-local allergic conjunctivitis.

We previously reported that 16.9% of allergic conjunctival disease cases were local allergic conjunctivitis (LAC). We therefore retrospectively investigated the pathological and clinical changes of LAC. Tear, conjunctival, and blood tests were performed on 313 patients with allergic conjunctival disease. A total of 313 patients with allergic conjunctival disease were surveyed using tear, conjunctival, and blood tests and QOL Questionnaire. In addition, we retrospectively examined the clinical test results of patients who agreed to re-examination more than one year after being diagnosed with LAC. Of the 313 cases, 44 were diagnosed as LAC (age ranged in 11-85 years (mean 67.8 years)) and 269 were diagnosed as non-LAC (7-92 years (mean 58.2 years)). There were 6 males (13.6%) and 38 females (86.4%), with more females even after age adjustment (p = 0.043). A QOL survey showed that LAC was characterized by less interference with daily life than non-LAC. After re-examination, 6 of 12 patients (50.0%) remained with LAC, while the remaining half changed to non-LAC. LAC was more common in older women than non-LAC. Considering the clinical change from LAC to non-LAC, it is speculated that the pathology of LAC may change over time.