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沙特阿拉伯两家医院全麻下儿童牙科治疗中预防性抗生素方案的评估:一项半实验性研究

Assessment of prophylactic antibiotics protocols in paediatric dental treatment under general anaesthesia in two Saudi-Arabian Hospitals: a quasi-study.

作者信息

Al-Namankany A

机构信息

Pediatric Dentistry Division, The Department of Preventive Dental Sciences, Faculty of Dentistry, Taibah University, P.O. Box 41141, 38008, Madinah, Madinah, Saudi Arabia.

出版信息

Eur Arch Paediatr Dent. 2025 Jun;26(3):571-579. doi: 10.1007/s40368-025-01026-5. Epub 2025 Apr 13.

DOI:10.1007/s40368-025-01026-5
PMID:40221630
Abstract

PURPOSE

While the use of antibiotics could increase the development of antibiotic-resistant microorganisms, yet, it is a standard protocol in some hospitals. Therefore, the purpose of this study was to debate this protocol by assessing the effects of prophylactic antibiotics in paediatric dental rehabilitation under general anaesthesia.

METHODS

This is a quasi-study comparing existing healthy (n = 46) children aged between 3 and 6 years at two hospitals in Saudi Arabia to assess the effects of prophylactic antibiotics in paediatric dental rehabilitation under general anaesthesia. The infection condition was identified by measuring fever, and periapical lesions.

RESULTS

No significant differences were reported in both terms. Infections in terms of fever (P = 0.295), the results revealed that 95.7% of children in the antibiotic group had no infections, whereas in the no-antibiotic group, 87% showed no infections. In terms of periapical lesions, 87.0% of the first group exhibited no periapical lesions (P = 0.343), while 8.7% had "1" (vertical bone defects or both), and 4.3% fell into the "2" category. Similarly, in the control group, 87.0% showed no periapical lesions, while 13.0% had infections.

CONCLUSION

Within the limitations of the present quasi-study in two Saudi-Arabian hospitals, it has been shown that although prophylactic antibiotics are still routine in some hospitals, their use is not justified in paediatric dental rehabilitation under general anaesthesia. Updating the relevant protocols in such operations is strongly recommended.

摘要

目的

虽然使用抗生素会增加抗生素耐药微生物的产生,但在一些医院这仍是标准方案。因此,本研究的目的是通过评估预防性抗生素在全身麻醉下儿童牙科康复中的作用来探讨该方案。

方法

这是一项准研究,比较沙特阿拉伯两家医院中46名3至6岁的健康儿童,以评估预防性抗生素在全身麻醉下儿童牙科康复中的作用。通过测量体温和根尖周病变来确定感染情况。

结果

在这两个方面均未报告显著差异。在发热方面的感染情况(P = 0.295),结果显示抗生素组中95.7%的儿童没有感染,而在无抗生素组中,87%没有感染。在根尖周病变方面,第一组中87.0%没有根尖周病变(P = 0.343),而8.7%有“1”级(垂直骨缺损或两者皆有),4.3%属于“2”级。同样,在对照组中,87.0%没有根尖周病变,而13.0%有感染情况。

结论

在沙特阿拉伯两家医院开展的这项准研究的局限性范围内,研究表明,虽然预防性抗生素在一些医院仍是常规用药,但在全身麻醉下的儿童牙科康复中使用预防性抗生素并不合理。强烈建议更新此类手术的相关方案。

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抗生素预防对与牙科操作相关的菌血症的发生率、性质、程度和持续时间的影响:系统评价。
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