Millman R P, Kimmel P L, Shore E T, Wasserstein A G
Nephron. 1985;40(4):407-10. doi: 10.1159/000183509.
After the discovery of sleep apnea in 2 patients receiving chronic maintenance hemodialysis, we decided to survey all 29 male patients undergoing outpatient dialysis for symptoms suggestive of sleep apnea. 12 of 29 (41%) had positive clinical histories. 8 of these patients consented to undergo all-night polysomnography. 6 were found to have sleep apnea which was primarily obstructive in type. Recent information has implicated testosterone administration in the development of obstructive sleep apnea. Therefore, polysomnography was performed in 5 of the patients both on and off weekly testosterone injections which they were receiving to stimulate erythropoiesis. There was no change in sleep complaints or a decrease in the number of apneas and hypopneas off therapy. Sleep apnea should be considered in symptomatic male dialysis patients. Its causation is presently unknown but it does not appear to be solely related to the administration of testosterone.
在2例接受慢性维持性血液透析的患者中发现睡眠呼吸暂停后，我们决定对所有29例接受门诊透析且有睡眠呼吸暂停症状的男性患者进行调查。29例中有12例（41%）有阳性临床病史。其中8例患者同意接受整夜多导睡眠图检查。发现6例患有睡眠呼吸暂停，主要为阻塞性类型。最近的信息表明，睾酮给药与阻塞性睡眠呼吸暂停的发生有关。因此，对5例正在接受每周一次睾酮注射以刺激红细胞生成的患者进行了多导睡眠图检查，他们在接受治疗和停止治疗时均进行了检查。治疗停止后，睡眠主诉没有变化，呼吸暂停和呼吸不足的次数也没有减少。有症状的男性透析患者应考虑睡眠呼吸暂停。其病因目前尚不清楚，但似乎不仅仅与睾酮给药有关。
