Mendelson W B, Wadhwa N K, Greenberg H E, Gujavarty K, Bergofsky E
Department of Psychiatry, State University of New York, Stony Brook 11794-8101.
Clin Nephrol. 1990 May;33(5):247-51.
A high prevalence of sleep apnea syndrome has been reported in previous studies of patients with chronic renal failure. The possible effects of chronic hemodialysis on the magnitude and severity of sleep apnea have not yet been clarified. The present study was undertaken to understand this relationship, by examining subjective and objective measures of sleep on nights following hemodialysis compared to those without hemodialysis. Significant sleep apnea was noted in 6 of 11 patients. The percentage of apnea time comprised of obstructive apneas increased significantly on the nights following hemodialysis. No significant differences occurred between these nights in the subjective or EEG measures of sleep, or in the total number of disordered breathing events or level of arterial oxygen desaturation. The association between end-stage renal disease (ESRD) and sleep apnea syndrome remains highly significant, but seems not to be acutely altered by conventional hemodialysis treatment.
在先前对慢性肾衰竭患者的研究中，已有报道称睡眠呼吸暂停综合征的患病率很高。慢性血液透析对睡眠呼吸暂停的程度和严重程度可能产生的影响尚未明确。本研究旨在通过检查血液透析后夜晚与未进行血液透析夜晚的主观和客观睡眠指标来了解这种关系。11名患者中有6名出现明显的睡眠呼吸暂停。血液透析后夜晚，阻塞性呼吸暂停占呼吸暂停时间的百分比显著增加。在这些夜晚之间，睡眠的主观指标或脑电图指标、呼吸紊乱事件总数或动脉血氧饱和度水平均无显著差异。终末期肾病（ESRD）与睡眠呼吸暂停综合征之间的关联仍然非常显著，但似乎不会因传统血液透析治疗而急性改变。
