Modai D, Weissgarten J, Shaked U, Segal S, Pik A, Fuchs R
Nephron. 1985;40(4):436-9. doi: 10.1159/000183515.
Uremic serum inhibits thymidine incorporation of phytohemagglutinin-stimulated lymphocytes originating in normal individuals. In this study the effect of levamisole on such inhibition was investigated. Preincubation with a wide range of levamisole concentrations resulted in complete prevention of the inhibitory effect imposed by uremic serum on thymidine incorporation. We would like to suggest that uremic serum possibly inhibits thymidine incorporation of normal lymphocytes by imposing an abnormal cyclic GMP/cyclic AMP intracellular ratio, and that levamisole may restore this ratio to normal.
尿毒症血清可抑制源于正常个体的经植物血凝素刺激的淋巴细胞摄取胸苷。在本研究中，对左旋咪唑对此种抑制作用的影响进行了调查。用多种浓度的左旋咪唑进行预孵育可完全防止尿毒症血清对胸苷摄取所施加的抑制作用。我们认为，尿毒症血清可能通过使细胞内环磷酸鸟苷/环磷酸腺苷比例异常而抑制正常淋巴细胞摄取胸苷，而左旋咪唑可能使该比例恢复正常。
