Modai D, Hadi Y, Weissgarten J, Peller S, Kaufman S
Immunol Lett. 1985;9(5):275-8. doi: 10.1016/0165-2478(85)90007-0.
Uremic sera are known to inhibit thymidine incorporation of normal lymphocytes. The nature of the factor(s) responsible for this inhibitory effect has not been completely elucidated. In this study a possible correlation was investigated between a number of uremic blood constituents altered with the progression of the disease and the immunoinhibitory effect of the respective sera. No such correlation was found with the values of hematocrit, urea, creatinine, calcium and phosphorus. On the other hand a significant negative correlation emerged between H+ and Mg2+ ion levels and the inhibition imposed on normal lymphocyte thymidine incorporation. This apparently paradoxical result would indicate that with regard to these two parameters the greater the severity of renal failure the smaller would be the immunoinhibitory effect of the respective serum. The inhibition imposed by uremic serum on immune functions is probably a multifactorial phenomenon, in which H+ and Mg2+ might play a role antagonistic to inhibitory factors.
已知尿毒症血清可抑制正常淋巴细胞摄取胸腺嘧啶核苷。造成这种抑制作用的因子的性质尚未完全阐明。在本研究中，对一些随疾病进展而改变的尿毒症血液成分与相应血清的免疫抑制作用之间可能存在的相关性进行了研究。未发现血细胞比容、尿素、肌酐、钙和磷的值与这种相关性有关。另一方面，H⁺和Mg²⁺离子水平与对正常淋巴细胞胸腺嘧啶核苷摄取的抑制作用之间出现了显著的负相关。这一明显矛盾的结果表明，就这两个参数而言，肾衰竭越严重，相应血清的免疫抑制作用就越小。尿毒症血清对免疫功能的抑制作用可能是一种多因素现象，其中H⁺和Mg²⁺可能对抑制因子起拮抗作用。
