成为一种GEM：生物封闭、环境应用、基因工程微生物。
Be a GEM: Biocontained, environmentally applied, genetically engineered microbes.
作者信息
Moon Tae Seok
机构信息
Synthetic Biology Group, J. Craig Venter Institute, La Jolla, CA, United States.
出版信息
Adv Drug Deliv Rev. 2025 Jun;221:115578. doi: 10.1016/j.addr.2025.115578. Epub 2025 Apr 11.
Abstract
Technological advances in engineering biology or synthetic biology have enabled practical applications of genetically engineered microbes (GEMs), including their use as living diagnostics and vehicles for therapeutics. However, technological and non-technological issues associated with biocontainment of GEMs have yet to be addressed before fully realizing their potential. In this short perspective, I briefly discuss the relevant technologies for GEM biocontainment as well as environmental impacts, regulatory issues, and public perception of GEMs.
摘要
工程生物学或合成生物学的技术进步已使基因工程微生物（GEMs）得到实际应用，包括将其用作活体诊断工具和治疗载体。然而，在充分实现其潜力之前，与GEMs生物防护相关的技术和非技术问题仍有待解决。在这篇简短的观点文章中，我简要讨论了GEMs生物防护的相关技术以及环境影响、监管问题和公众对GEMs的看法。
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