Nagayama Masao
Department of Neurology, International University of Health and Welfare (IUHW) Graduate School of Medicine / Narita Hospital.
Brain Nerve. 2025 Apr;77(4):337-345. doi: 10.11477/mf.188160960770040337.
Brain death/death by neurologic criteria (BD/DNC) is a diagnostic guideline that defines the irreversible cessation of all functions of the brain, including both cerebral hemispheres and the brainstem, resulting from massive organic brain damage. In 2020, the World Brain Death Project, an international collaborative endorsed by 27 international societies, published comprehensive guidelines regarding the standardization of terminology and criteria for the accurate determination of BD/DNC in adults and children. In 2023, the updated and integrated 2010 American Academy of Neurology brain death guidelines for adults and the 2011 American Academy of Pediatrics, Child Neurology Society, and Society of Critical Care Medicine guidelines for infants and children were published. In this article, the current concepts of BD/DNC and the practice of BD/DNC determination in Japan and worldwide are reviewed, along with the most recent developments.
脑死亡/基于神经学标准的死亡（BD/DNC）是一种诊断指南，其定义为由于严重的器质性脑损伤导致包括大脑两半球和脑干在内的脑的所有功能不可逆转地停止。2020年，由27个国际学会认可的国际合作项目世界脑死亡项目发布了关于准确判定成人和儿童BD/DNC的术语和标准标准化的综合指南。2023年，更新并整合后的2010年美国神经病学学会成人脑死亡指南以及2011年美国儿科学会、儿童神经病学会和危重病医学会婴儿及儿童脑死亡指南得以发布。在本文中，将对BD/DNC的当前概念以及日本和全球范围内BD/DNC判定的实践情况，连同最新进展进行综述。
