Jiang Ting, Fei Lixue
Cancer Center, The First Bethune Hospital of Jilin University, Changchun, 130000, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 14. doi: 10.1007/s00210-025-04141-8.
Melanocytes are the source of the skin cancer known as melanoma. It usually affects the viscera, mucous membranes, and skin. Even so, melanoma only makes for 7% of all skin cancer occurrences. By triggering the generation of type I interferons (IFN-I) and inflammatory cytokines upon identifying microbial DNA, the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway promotes anti-microbial innate immunity. A growing body of research indicates that antitumor immunity depends on the cGAS-STING axis being activated. The cGAS-STING-regulated downstream cytokines, particularly IFN-I, act as linkages between adaptive and innate immunity. As a result, an increasing amount of research has concentrated on the synthesis and screening of agonists of the STING pathway. As a result, an increasing amount of research has concentrated on the synthesis and screening of agonists of the STING pathway. The many implications of the cGAS-STING pathway in the pathophysiology and therapy of melanoma are thoroughly examined in this study. Our research highlights the significance of the cGAS-STING pathway in melanoma and identifies it as a key target for boosting immunity against tumors.
黑素细胞是被称为黑色素瘤的皮肤癌的来源。它通常影响内脏、黏膜和皮肤。即便如此，黑色素瘤仅占所有皮肤癌病例的7%。环磷酸鸟苷-腺苷酸合成酶（cGAS）-干扰素基因刺激因子（STING）通路通过在识别微生物DNA时触发I型干扰素（IFN-I）和炎性细胞因子的产生，促进抗微生物固有免疫。越来越多的研究表明，抗肿瘤免疫依赖于被激活的cGAS-STING轴。cGAS-STING调节的下游细胞因子，特别是IFN-I，充当适应性免疫和固有免疫之间的联系。因此，越来越多的研究集中在STING通路激动剂的合成和筛选上。本研究全面探讨了cGAS-STING通路在黑色素瘤病理生理学和治疗中的诸多影响。我们的研究突出了cGAS-STING通路在黑色素瘤中的重要性，并将其确定为增强抗肿瘤免疫力的关键靶点。
