Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom.
Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom.
Curr Opin Immunol. 2024 Dec;91:102484. doi: 10.1016/j.coi.2024.102484. Epub 2024 Oct 1.
B cells experience extreme alterations in their metabolism throughout their life cycle, from naïve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high levels of protein production that can persist for decades. The underpinning of these transitions remains incompletely understood, and a key question is how utilisation of fuel source supports B cell metabolism. For example, GC B cells, unlike almost all rapidly proliferating cells, mainly use fatty acid oxidation rather than glycolysis. However, following differentiation to plasma cells, their metabolism switches towards a high rate of glucose consumption to aid antibody production. In this review, we discuss the key metabolic pathways in B cells, linking them to cellular signalling events and placing them in the context of disease and therapeutic potential.
B 细胞在其生命周期中经历代谢的剧烈变化，从幼稚 B 细胞（活性最低）到生发中心（GC）B 细胞（所有细胞中增殖最快），再到长寿浆细胞，其蛋白质产生水平非常高，可持续数十年。这些转变的基础仍不完全清楚，一个关键问题是燃料来源的利用如何支持 B 细胞代谢。例如，GC B 细胞与几乎所有快速增殖的细胞不同，主要利用脂肪酸氧化而不是糖酵解。然而，在分化为浆细胞后，它们的代谢转向高葡萄糖消耗率，以帮助抗体产生。在这篇综述中，我们讨论了 B 细胞中的关键代谢途径，将它们与细胞信号事件联系起来，并将它们置于疾病和治疗潜力的背景下。
