Gao Xinyi, Guo Lianrui, Gao Xixiang, Guo Jianming, Cui Shijun, Tong Zhu, Gu Yongquan
Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, Peoples Republic of China.
Vasa. 2025 Jul;54(4):265-272. doi: 10.1024/0301-1526/a001196. Epub 2025 Apr 14.
To investigate the efficacy of Chocolate balloon use as an adjunct to drug-coated balloon (DCB) angioplasty for the treatment of femoropopliteal lesions. This retrospective study was performed with a 12-month follow-up period. The rate of flow-limiting dissection, primary patency, rate and length of bailout stenting, and freedom from major adverse limb events (MALEs) were compared between femoropopliteal lesions treated with plain balloons (PBs) and those treated with Chocolate balloons combined with DCB angioplasty. In total, 192 patients (197 de-novo lesions) were included: 137 patients (141 lesions) in the PB group and 55 patients (56 lesions) in the Chocolate balloon group. The mean total lesion lengths were 126.84±71.57 and 138.39±65.35 mm (P=0.297), more than half of patients had chronic total occlusion (53.2% and 51.8%, P=0.859), the rates of flow-limiting dissection were 15.6% and 12.5% (P=0.579). Rates of primary patency were 88.1% and 92.6%, respectively. Chocolate balloon use reduced the mean total bailout stenting length (135.17±68.85 vs. 98.24±36.78 mm, P=0.022), including in complex lesions (180±70.43 vs. 102.50±44.64 mm, P=0.011), and the absolute bailout stenting length (total bailout stenting/lesion length ratio; 0.74±0.24 vs. 0.48±0.19, P=0.017). Relative to PB, Chocolate balloon use combined with DCB angioplasty did not show a significant advantage. It did, however, reduce the absolute total bailout stenting length in complex lesions.
探讨巧克力球囊作为药物涂层球囊（DCB）血管成形术辅助手段治疗股腘动脉病变的疗效。本回顾性研究进行了为期12个月的随访。比较了使用普通球囊（PB）治疗的股腘动脉病变与使用巧克力球囊联合DCB血管成形术治疗的股腘动脉病变的限流性夹层发生率、初始通畅率、补救性支架置入率和长度以及无主要肢体不良事件（MALE）的情况。总共纳入了192例患者（197处新发病变）：PB组137例患者（141处病变），巧克力球囊组55例患者（56处病变）。平均总病变长度分别为126.84±71.57和138.39±65.35毫米（P=0.297），超过一半的患者患有慢性完全闭塞（分别为53.2%和51.8%，P=0.859），限流性夹层发生率分别为15.6%和12.5%（P=0.579）。初始通畅率分别为88.1%和92.6%。使用巧克力球囊减少了平均总补救性支架置入长度（135.17±68.85与98.24±36.78毫米，P=0.022），包括在复杂病变中（180±70.43与102.50±44.64毫米，P=0.011），以及绝对补救性支架置入长度（总补救性支架置入长度/病变长度比；0.74±0.24与0.48±0.19，P=0.017）。相对于PB，巧克力球囊联合DCB血管成形术未显示出显著优势。然而，它确实减少了复杂病变中的绝对总补救性支架置入长度。
