Globus M, Mildworf B, Melamed E
Neurology. 1985 Aug;35(8):1135-9. doi: 10.1212/wnl.35.8.1135.
In Parkinson's disease, there is high prevalence of dementia, reduction of the regional cerebral blood flow (rCBF), and neuronal loss and Alzheimer-like pathologic changes in cerebral cortex. Since rCBF is also decreased in Alzheimer's dementia, it is theoretically possible that both decreases in rCBF and cognitive impairment in parkinsonians are caused by a similar mechanism, eg, reduced metabolic demand or loss of cholinergic neurons innervating cortex and microvessels. We therefore measured rCBF using the 133Xenon inhalation technique and evaluated cognitive function with a detailed neuropsychological test battery in 48 patients with Parkinson's disease. Mean brain, hemispheric, and regional flows were decreased in parkinsonians as compared with those in age-matched controls. Most of the cognitive functions were impaired in patients as compared with those in normal subjects. However, there was no correlation between the magnitude of rCBF reduction and the presence and severity of intellectual deterioration in parkinsonians, suggesting that each may be caused by a different mechanism.
在帕金森病中，痴呆的患病率很高，局部脑血流量（rCBF）减少，大脑皮质存在神经元丢失及类似阿尔茨海默病的病理改变。由于在阿尔茨海默病性痴呆中rCBF也降低，理论上帕金森病患者rCBF降低和认知障碍可能由相似机制引起，例如代谢需求降低或支配皮质和微血管的胆碱能神经元丢失。因此，我们采用133氙吸入技术测量了48例帕金森病患者的rCBF，并使用一套详细的神经心理学测试量表评估了其认知功能。与年龄匹配的对照组相比，帕金森病患者的平均全脑、半球及局部血流量均降低。与正常受试者相比，患者的大多数认知功能均受损。然而，帕金森病患者rCBF降低的程度与智力衰退的存在及严重程度之间并无相关性，这表明二者可能由不同机制所致。
