Lavy S, Melamed E, Cooper G, Bentin S, Rinot Y
Arch Neurol. 1979 Jun;36(6):344-8. doi: 10.1001/archneur.1979.00500420054005.
Regional cerebral blood flow (rCBF) was measured by the xenon 133 inhalation method in 60 patients with Parkinson's disease and compared with flow data obtained in 51 age-matched normal control subjects. Mean brain rCBF was significantly reduced in patients with parkinsonism (9.5%, P less than .001). The most marked and significant rCBF decreases were observed in the older patients (18.8%, P less than .001). There was no correlation between degree of rCBF reduction and duration of parkinsonism. Decreases in hemispheric mean rCBF values were similar in both hemispheres even in patients with unilateral signs. The present study provides additional evidence for involvement of the cerebral cortex in Parkinson's disease. The rCBF decline may be associated in part with high prevalence of mental impairment and cortical atrophy and with diminished cerebral metabolic rate due to brain dopamine deficiency in patients with parkinsonism.
采用氙133吸入法对60例帕金森病患者进行局部脑血流量（rCBF）测定，并与51例年龄匹配的正常对照者的血流数据进行比较。帕金森病患者的平均脑rCBF显著降低（9.5%，P<0.001）。年龄较大的患者rCBF下降最为明显且显著（18.8%，P<0.001）。rCBF降低程度与帕金森病病程之间无相关性。即使是有单侧症状的患者，两个半球的半球平均rCBF值下降也相似。本研究为大脑皮质参与帕金森病提供了更多证据。rCBF下降可能部分与帕金森病患者精神障碍和皮质萎缩的高患病率以及由于脑多巴胺缺乏导致的脑代谢率降低有关。
