代谢对话塑造肿瘤微环境中的免疫反应。

Gao Fengxia, Shah Rushil, Xin Gang, Wang Ruoning

Department of Microbial Infection and Immunity, Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, Ohio, USA.

Center for Childhood Cancer Research, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.

Eur J Immunol. 2025 Apr;55(4):e202451102. doi: 10.1002/eji.202451102.

The fate of immune cells is fundamentally linked to their metabolic program, which is also influenced by the metabolic landscape of their environment. The tumor microenvironment represents a unique system for intercellular metabolic interactions, where tumor-derived metabolites suppress effector CD8 T cells and promote tumor-promoting macrophages, reinforcing an immune-suppressive niche. This review will discuss recent advancements in metabolism research, exploring the interplay between various metabolites and their effects on immune cells within the tumor microenvironment.

免疫细胞的命运与其代谢程序密切相关，而代谢程序也受其周围代谢环境的影响。肿瘤微环境代表了一个独特的细胞间代谢相互作用系统，肿瘤衍生的代谢产物在其中会抑制效应性CD8 T细胞，并促进具有肿瘤促进作用的巨噬细胞，从而强化免疫抑制微环境。本综述将讨论代谢研究的最新进展，探讨肿瘤微环境中各种代谢产物之间的相互作用及其对免疫细胞的影响。