Li Di, Zhang Chi, Xiong Qirong, Liu Wylie, Tang Yingwei, Liang Li, Pu Kanyi, Duan Hongwei
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
Raffles Institution, 1 Raffles Institution Lane, Singapore 575954, Singapore.
ACS Nano. 2025 Apr 22;19(15):15040-15054. doi: 10.1021/acsnano.5c01566. Epub 2025 Apr 14.
Targeted delivery of therapeutic agents to malignant tissues is crucial for enhancing clinical outcomes and reducing side effects. Magnetic nanorobots (MNRs) present a promising strategy for controlled delivery, leveraging external magnetic fields to achieve precise in vivo targeting. This work develops elongated MNRs comprising linearly arranged magnetic nanoparticles linked by metal-polyphenol complexes (MPCs) for magnetic-field-directed active tumor targeting and synergistic tumor therapy. The MNRs are created by assembling 30 nm FeO nanoparticles, tannic acid, and ferrous ions (Fe) under a uniform magnetic field, resulting in elongated chain-like structures fixed by MPCs, which also promotes peroxidase-like activity. These structures show a greater magnetic response than individual nanoparticles, offering flexibility in magnetic manipulation. The MPCs coating allows tailored surface modifications with glucose oxidase, copper ions (Cu), and human serum albumin (HSA), producing colloidally stable MNRs with a built-in multienzymatic cascade (MNRs@GOx/Cu/HSA) that consumes glucose, generates OH, and depletes the antioxidant glutathione (GSH). Collectively, surface-engineered multifunctional MNRs demonstrate improved in vivo tumor targeting driven by external magnetic fields, leading to efficient localized chemodynamic therapy. The tailored structural and functional properties of the developed MNRs render them suitable for targeted cargo delivery, minimally invasive surgery, and localized treatments in disease sites.
将治疗剂靶向递送至恶性组织对于提高临床疗效和减少副作用至关重要。磁性纳米机器人（MNRs）为可控递送提供了一种有前景的策略，利用外部磁场在体内实现精确靶向。这项工作开发了一种细长的MNRs，它由通过金属多酚复合物（MPCs）连接的线性排列的磁性纳米颗粒组成，用于磁场导向的主动肿瘤靶向和协同肿瘤治疗。通过在均匀磁场下组装30nm的FeO纳米颗粒、单宁酸和亚铁离子（Fe）来制备MNRs，从而形成由MPCs固定的细长链状结构，这也促进了过氧化物酶样活性。这些结构比单个纳米颗粒表现出更大的磁响应，在磁操纵方面具有灵活性。MPCs涂层允许用葡萄糖氧化酶、铜离子（Cu）和人血清白蛋白（HSA）进行定制的表面修饰，从而产生具有内置多酶级联反应（MNRs@GOx/Cu/HSA）的胶体稳定的MNRs，该反应消耗葡萄糖、产生OH并消耗抗氧化剂谷胱甘肽（GSH）。总的来说，表面工程化的多功能MNRs在外部磁场驱动下表现出改善的体内肿瘤靶向性，从而实现高效的局部化学动力学治疗。所开发的MNRs定制的结构和功能特性使其适用于靶向货物递送、微创手术和疾病部位的局部治疗。
