孕期血清三碘甲状腺原氨酸及校正三碘甲状腺原氨酸（游离三碘甲状腺原氨酸指数）的评估

Evaluation of serum triiodothyronine and adjusted triiodothyronine (free triiodothyronine index) in pregnancy.

作者信息

Parslow M E, Oddie T H, Fisher D A

出版信息

Clin Chem. 1977 Mar;23(3):490-2.

Abstract

We measured serum thyroxine (free and total), triiodothyronine (free and total), thyroxine-binding globulin, and triiodothyronine uptake by talc in 97 normal men and 50 pregnant women. Mean serum thyroxine and triiodothyronine concentrations were higher in the pregnant subjects (104 vs. 78 mug/liter and 1.69 vs. 1.30 mug/liter) because of a higher mean thyroxine-binding globulin concentration (70 vs. 38 mg/liter). Mean triiodothyronine uptake by talc was lower in the pregnant subjects (0.82 vs. 1.03). Mean free thyroxine concentrations were similar in the two groups, but mean free triiodothyronine concentrations were 10% lower in the pregnant subjects. Triiodothyronine uptake by talc and the diayzable thyroxine and triiodothyronine fractions were highly correlated (r = 0.85 and r = 0.82, P less than 0.001). Calculated free thyroxine index and free triiodothyronine index values (hyroxine and triiodothyronine indirectly adjusted, using triiodothyronine talc uptake to compensate for differences in thyroxine-binding globulin concentration), were statistically similar (84 vs. 82 and 1.38 vs. 1.34) in pregnant and male subjects. The results indicate that the total triiodothyronine concentration can be normalized on the basis of the triiodothyronine uptake by talc to correct for variations in thyroxine-binding globulin concentration.

摘要

我们检测了97名正常男性和50名孕妇的血清甲状腺素（游离和总甲状腺素）、三碘甲状腺原氨酸（游离和总三碘甲状腺原氨酸）、甲状腺素结合球蛋白以及滑石粉对三碘甲状腺原氨酸的摄取情况。孕妇组血清甲状腺素和三碘甲状腺原氨酸的平均浓度较高（分别为104 vs. 78μg/升和1.69 vs. 1.30μg/升），原因是甲状腺素结合球蛋白的平均浓度较高（70 vs. 38mg/升）。孕妇组滑石粉对三碘甲状腺原氨酸的平均摄取较低（0.82 vs. 1.03）。两组的游离甲状腺素平均浓度相似，但孕妇组游离三碘甲状腺原氨酸的平均浓度低10%。滑石粉对三碘甲状腺原氨酸的摄取与可透析的甲状腺素和三碘甲状腺原氨酸部分高度相关（r = 0.85和r = 0.82，P < 0.001）。计算得出的游离甲状腺素指数和游离三碘甲状腺原氨酸指数值（使用滑石粉对三碘甲状腺原氨酸的摄取来间接调整甲状腺素和三碘甲状腺原氨酸，以补偿甲状腺素结合球蛋白浓度的差异），在孕妇和男性受试者中具有统计学相似性（84 vs. 82和1.38 vs. 1.34）。结果表明，基于滑石粉对三碘甲状腺原氨酸的摄取，总三碘甲状腺原氨酸浓度可进行标准化，以校正甲状腺素结合球蛋白浓度的变化。