Jaramillo B A, Ganjei P, Averette H E, Sevin B U, Lovecchio J L
Obstet Gynecol. 1985 Sep;66(3):398-401.
During the years 1969 to 1982, 16 patients with primary malignant melanoma of the vulva were entered into the Tumor Registry at the University of Miami Jackson Memorial Medical Center. The mean age was 55, with a range of 18 to 89 years. Treatment was primarily by radial vulvectomy with bilateral groin and pelvic node dissection. Survival was correlated to FIGO staging, Clark and Breslow classifications, and lymph node involvement. Survival correlated best to tumor thickness and Clark levels. Patients with Clark level 2 or less and less than 1.5 mm depth of penetration had the best prognosis. Lymph node involvement was present in 25% of the patients, and there were no survivors in this group. There were no instances of positive pelvic nodes when the groin nodes were negative, and routine pelvic lymphadenectomy is not recommended.
1969年至1982年期间，16例原发性外阴恶性黑色素瘤患者被录入迈阿密大学杰克逊纪念医学中心的肿瘤登记处。平均年龄为55岁，范围在18岁至89岁之间。治疗主要采用根治性外阴切除术加双侧腹股沟和盆腔淋巴结清扫术。生存率与国际妇产科联盟（FIGO）分期、克拉克（Clark）和布雷斯洛（Breslow）分类以及淋巴结受累情况相关。生存率与肿瘤厚度和克拉克分级的相关性最佳。克拉克分级为2级或更低且浸润深度小于1.5毫米的患者预后最佳。25%的患者存在淋巴结受累，该组无幸存者。当腹股沟淋巴结为阴性时，盆腔淋巴结无阳性病例，因此不建议常规进行盆腔淋巴结清扫术。
