Fisher J B, Edgren B E, Mammel M C, Coleman J M
Obstet Gynecol. 1985 Sep;66(3 Suppl):34S-35S.
A 2750-g female infant was born at 36 weeks' gestation to a 40-year-old woman treated with clonazepam throughout her pregnancy. The infant developed apnea, cyanosis, and hypotonia within a few hours of birth. The mother's serum clonazepam level at delivery was 32 ng/mL; the cord blood level was 19 ng/mL. The infant had no congenital malformations, evidence of infection, or seizures. Clinical episodes ceased by ten days of age. The woman elected to breastfeed; breast milk clonazepam levels were between 11 and 13 ng/mL. She was discharged with a cardiorespiratory monitor. The authors suggest that infants of mothers receiving this agent during pregnancy or while nursing have serum levels measured. Additionally, these infants should be monitored for central nervous system depression or apnea.
一名2750克的女婴在孕36周时出生，其母亲为一名40岁女性，整个孕期都在服用氯硝西泮。婴儿在出生后数小时内出现呼吸暂停、青紫和肌张力减退。母亲分娩时血清氯硝西泮水平为32纳克/毫升；脐血水平为19纳克/毫升。婴儿无先天性畸形、感染迹象或癫痫发作。临床症状在出生十天时停止。母亲选择母乳喂养；母乳中氯硝西泮水平在11至13纳克/毫升之间。她带着心肺监护仪出院。作者建议，对孕期或哺乳期服用该药物母亲的婴儿测量血清水平。此外，这些婴儿应监测是否有中枢神经系统抑制或呼吸暂停。
