Asghari Baghkheirati Amir, Golmohammadi Reza, Sekhavati Mohammad Hadi, Razmyar Jamshid, Abyazi Mohammad Ali
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Avian Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Iran J Biotechnol. 2024 Oct 1;22(4):e3913. doi: 10.30498/ijb.2024.455700.3913. eCollection 2024 Oct.
Antibiotic resistance has become a major public health concern worldwide. Treatment of humans and animals is becoming increasingly challenging due to antibiotic resistance. Antibiotic-resistant bacteria can be transmitted from animals to humans by several routes, including direct contact, contaminated food or water, or environmental exposure. Various factors contribute to the rising problem, such as the widespread and indiscriminate exploitation of antimicrobials in both human and animal healthcare, over-prescription, misuse of antibiotics, the role of agriculture in spreading antibiotic resistance, and poor animal husbandry practices. According to the preliminary findings, recombinant antimicrobial peptides are an interesting novel area of biotechnology and medical innovation that might be employed as a secure and effective substitute for antibiotics. In this review study, we briefly examine the factors contributing to the rise of antibiotic resistance. We then introduce and discuss recombinant antimicrobial peptides as a promising strategy to address this growing problem.
抗生素耐药性已成为全球主要的公共卫生问题。由于抗生素耐药性，人类和动物的治疗正变得越来越具有挑战性。耐抗生素细菌可通过多种途径从动物传播给人类，包括直接接触、受污染的食物或水，或环境暴露。各种因素导致了这一问题的加剧，例如在人类和动物医疗保健中广泛且无差别地使用抗菌药物、过度处方、抗生素的滥用、农业在传播抗生素耐药性中的作用以及不良的畜牧 practices。根据初步研究结果，重组抗菌肽是生物技术和医学创新中一个有趣的新领域，有望作为抗生素的安全有效替代品。在本综述研究中，我们简要探讨了导致抗生素耐药性上升的因素。然后，我们介绍并讨论重组抗菌肽，将其作为解决这一日益严重问题的一种有前景的策略。
