da Ponte Thaís Fontenele, Fontenelle Lysiane Maria Adeodato Ramos, Rodrigues Carlos Ewerton Maia, Souza Jean Carlos, Rodrigues Emanuelle de Matos
Rheumatology, Fortaleza General Hospital, Fortaleza, BRA.
Medical Sciences, Medical School, University of Fortaleza, Fortaleza, BRA.
Cureus. 2025 Mar 12;17(3):e80459. doi: 10.7759/cureus.80459. eCollection 2025 Mar.
Systemic lupus erythematosus (SLE) is an autoimmune disease affecting several organs, including the kidneys, potentially leading to lupus nephritis (LN). SLE has also been associated with several neoplasias, but its relation to renal cell carcinoma (RCC) has been little explored. We report a young women diagnosed concomitantly with LN and RCC. The latter was discovered incidentally during an investigation of nephrotic syndrome and confirmed on histology and renal microscopy. The patient was submitted to partial nephrectomy and immunosuppression, with good outcome, as shown by the improvement in proteinuria and other symptoms. Our case highlights the complexity of diagnosing SLE in combination with RCC and the importance of permanent surveillance and multidisciplinary approach to optimize treatment.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，可累及包括肾脏在内的多个器官，有可能导致狼疮性肾炎（LN）。SLE还与多种肿瘤形成有关，但其与肾细胞癌（RCC）的关系鲜有研究。我们报告了一名同时被诊断为LN和RCC的年轻女性。后者是在对肾病综合征进行调查时偶然发现的，并经组织学和肾脏显微镜检查确诊。患者接受了部分肾切除术和免疫抑制治疗，蛋白尿和其他症状有所改善，预后良好。我们的病例突出了SLE合并RCC诊断的复杂性，以及长期监测和多学科方法对优化治疗的重要性。
