Hanh Tran Thi My, Hieu Nguyen Duy, Ngoc Vo Truong Nhu, Anh Le Kha, Thao Tran Phuong, Hau Dinh Nguyen My, Nga Dao Thi Hang
School of Dentistry, Hanoi Medical University, Hanoi, VNM.
Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Nagoya, JPN.
Cureus. 2025 Mar 12;17(3):e80445. doi: 10.7759/cureus.80445. eCollection 2025 Mar.
Chlorhexidine digluconate (CHX) is widely recognized for its antimicrobial properties and potential use as an irrigant in endodontic treatment. However, its specific role in the treatment of primary teeth remains uncertain. This review aimed to evaluate the effectiveness of CHX in cleaning the root canal system in pediatric endodontic treatment. A total of 46 studies were initially identified from three databases: PubMed (5), ScienceDirect (2), and Cochrane (0). Following selection based on PRISMA-ScR 2018 guidelines, seven studies met all inclusion criteria and were included in the qualitative analysis. The findings indicate that CHX 2% demonstrates good antibacterial efficacy but lacks the ability to dissolve inorganic tissue. Additionally, its safety and effectiveness in dissolving organic tissue in primary teeth have yet to be thoroughly investigated. The minimum irrigation volume when using CHX is 2 ml per root canal, which ensures optimal effectiveness in bacterial elimination and improves treatment outcomes. While CHX shows promise as an endodontic irrigation solution for primary teeth, further research is necessary to fully understand its potential benefits and limitations.
葡萄糖酸氯己定（CHX）因其抗菌特性以及在牙髓病治疗中作为冲洗剂的潜在用途而被广泛认可。然而，其在乳牙治疗中的具体作用仍不明确。本综述旨在评估CHX在儿童牙髓病治疗中清洁根管系统的有效性。最初从三个数据库中识别出46项研究：PubMed（5项）、ScienceDirect（2项）和Cochrane（0项）。根据PRISMA - ScR 2018指南进行筛选后，7项研究符合所有纳入标准并被纳入定性分析。研究结果表明，2%的CHX具有良好的抗菌效果，但缺乏溶解无机组织的能力。此外，其在乳牙中溶解有机组织的安全性和有效性尚未得到充分研究。使用CHX时的最小冲洗量为每根管2毫升，这可确保在细菌清除方面达到最佳效果并改善治疗结果。虽然CHX作为乳牙牙髓冲洗液显示出前景，但仍需要进一步研究以充分了解其潜在的益处和局限性。
