Johnson-Gray Elizabeth, Shaffer Austin J, Pandey Priyanka, Allareddy Greeshma, Franzen Matthias
Anesthesiology, OhioHealth Doctors Hospital, Columbus, USA.
Anesthesiology, Cleveland Clinic, Cleveland, USA.
Cureus. 2025 Mar 12;17(3):e80492. doi: 10.7759/cureus.80492. eCollection 2025 Mar.
Pseudocholinesterase (PCHE) deficiency is a rare condition that results in increased sensitivity to certain medications, including the paralytic agents succinylcholine and mivacurium. PCHE deficiency typically presents when patients cannot be weaned off the ventilator because of residual paralysis. These patients require mechanical ventilation and sedation until they are strong enough to be safely extubated. This report presents the case of a 53-year-old male patient whose only known surgical and anesthetic complication was post-op nausea and vomiting and who was diagnosed with PCHE deficiency after he could not be safely extubated in the operating room (OR) after a robotic inguinal hernia repair. The patient was admitted to the ICU and successfully extubated several hours later.
假性胆碱酯酶（PCHE）缺乏症是一种罕见病症，会导致对某些药物的敏感性增加，包括麻痹剂琥珀酰胆碱和米库氯铵。当患者因残余麻痹无法从呼吸机上撤机时，通常会出现PCHE缺乏症。这些患者需要机械通气和镇静，直到他们足够强壮能够安全拔管。本报告介绍了一名53岁男性患者的病例，其已知的唯一手术和麻醉并发症是术后恶心和呕吐，在机器人腹股沟疝修补术后在手术室（OR）无法安全拔管后被诊断为PCHE缺乏症。该患者被收入重症监护病房（ICU），数小时后成功拔管。
