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研究1-杂芳基苯并三唑银化合物的抗菌活性。

Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds.

作者信息

Elzein Ahmed, Al Jomeh Ghadah Abdullah S, Tizzard Graham J, Coles Simon J, Banti Christina N, Hadjikakou Sotiris K, Kostakis George E

机构信息

Department of Chemistry, School of Life Sciences, University of Sussex Brighton BN1 9QJ UK

UK National Crystallography Service, Chemistry, University of Southampton UK.

出版信息

RSC Adv. 2025 Apr 11;15(15):11431-11440. doi: 10.1039/d5ra01072a. eCollection 2025 Apr 9.

DOI:10.1039/d5ra01072a
PMID:40225772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11987083/
Abstract

Five (1-5) Ag(i) compounds, derived from different ,'-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(i) compounds in medicinal inorganic chemistry.

摘要

合成了五种（1 - 5种）源自不同的 '-双齿1 - 杂芳基苯并三唑配体的Ag(i)化合物，并使用同步辐射X射线衍射（SXRD）、红外光谱（IR）、紫外可见光谱（UV - Vis）、元素分析、电喷雾电离质谱（ESI - MS）和核磁共振（NMR）对其进行了表征。配体和抗衡阴离子的变化产生了不同的结构和形态。在二甲基亚砜（DMSO）中进行的微摩尔级初步抗菌测试表明，只有基于1 - (2 - 吡啶基)苯并三唑和三氟甲磺酸盐阴离子的化合物2表现出有趣的抗菌特性，从而标志着一类新型Ag(i)化合物在药用无机化学中的引入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/96d6853d81c7/d5ra01072a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/a0c8088f2865/d5ra01072a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/8f7c99167848/d5ra01072a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/66bbab9552f0/d5ra01072a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/96d6853d81c7/d5ra01072a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/a0c8088f2865/d5ra01072a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/8f7c99167848/d5ra01072a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/66bbab9552f0/d5ra01072a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14fb/11987083/96d6853d81c7/d5ra01072a-f1.jpg

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