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用于治疗压疮/损伤的水凝胶敷料开发的最新进展。

Recent advances in the development of hydrogel dressings for the treatment of pressure ulcers/injuries.

作者信息

Chen Ye, Jiang Weifang, Fu Yuwen, Li Mengting, Wang Yan, Zhuge Hengxian, Wang Tanchun

机构信息

Department of Quality Management, Affiliated Jinling Hospital, Medical School of Nanjing University Nanjing 210002, Jiangsu, China.

Department of Emergency, Affiliated Jinling Hospital, Medical School of Nanjing University Nanjing 210002, Jiangsu, China.

出版信息

Am J Transl Res. 2025 Mar 15;17(3):1613-1629. doi: 10.62347/YVQD6861. eCollection 2025.

Abstract

Pressure ulcers, also known as pressure injuries, are common conditions that result from chronic bedrest. These ulcers significantly affect quality of life and substantially burden individuals and society with health costs. The prevention and treatment of pressure ulcers is a primary concern for health care professionals. Dressings play a crucial role in the treatment of pressure ulcers. Hydrogels are innovative safe materials that show great promise for clinical applications. Recent research has demonstrated the potential of hydrogel dressings to promote the healing of pressure ulcers and chronic wounds. This review aims to summarize the mechanisms and effects of hydrogel dressings and to discuss considerations for their use in patients with pressure injuries under different circumstances. Hydrogel dressings, especially loaded with unique cargo, may represent promising new options for the treatment of pressure ulcers. However, additional clinical studies are urgently needed to validate the efficacy and accessibility of hydrogels in clinical practice.

摘要

压疮,也称为压力性损伤,是由长期卧床休息导致的常见病症。这些溃疡会显著影响生活质量,并给个人和社会带来巨大的健康成本负担。压疮的预防和治疗是医护人员的首要关注点。敷料在压疮治疗中起着至关重要的作用。水凝胶是创新的安全材料,在临床应用中显示出巨大潜力。最近的研究表明水凝胶敷料有促进压疮和慢性伤口愈合的潜力。本综述旨在总结水凝胶敷料的作用机制和效果,并讨论在不同情况下将其用于压力性损伤患者时的注意事项。水凝胶敷料,尤其是载有独特成分的敷料,可能是治疗压疮的有前景的新选择。然而,迫切需要更多的临床研究来验证水凝胶在临床实践中的疗效和可及性。

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