Gao Pei, Chen Beibei, Wang Luyao
Department of Gynecology, Hangzhou Women's Hospital No. 369 Kunpeng Road, Shangcheng District, Hangzhou 310008, Zhejiang, China.
Am J Transl Res. 2025 Mar 15;17(3):1568-1579. doi: 10.62347/TXKV6669. eCollection 2025.
Nausea and vomiting affect 50-80% of pregnant women, with a subset developing hyperemesis gravidarum (HG), a severe condition leading to weight loss and malnutrition. Given that over 28% of pregnant women globally seek herbal alternatives due to concerns about the safety of prescription medications, ginger has emerged as a popular remedy for such symptoms. This meta-analysis systematically evaluates the efficacy of ginger supplementation in managing HG based on clinical studies. Following PRISMA guidelines, a comprehensive search was conducted across PubMed, Cochrane, Scopus, ScienceDirect, and ResearchGate. Ten high-quality randomized controlled trials and comparative studies were included from a pool of 32 identified papers, based on strict eligibility criteria. These trials examined various forms of ginger supplementation (capsules, powders, biscuits) and compared them to controls such as placebos, vitamin B6, and metoclopramide. A pooled odds ratio of 0.41 (95% CI: 0.22-0.79, P = 0.008) indicated a significant reduction in nausea and vomiting symptoms. Ginger supplementation was well-tolerated with minimal side effects and no significant harm to maternal or fetal health. This analysis supports the inclusion of ginger as a safe, flexible, and effective non-pharmacologic treatment for HG symptoms in clinical practice.
恶心和呕吐影响50%-80%的孕妇，其中一部分会发展为妊娠剧吐（HG），这是一种导致体重减轻和营养不良的严重病症。鉴于全球超过28%的孕妇因担心处方药的安全性而寻求草药替代疗法，生姜已成为治疗此类症状的常用药物。这项荟萃分析基于临床研究系统地评估了补充生姜对治疗妊娠剧吐的疗效。按照PRISMA指南，对PubMed、Cochrane、Scopus、ScienceDirect和ResearchGate进行了全面检索。根据严格的纳入标准，从32篇已识别的论文中纳入了10项高质量的随机对照试验和比较研究。这些试验研究了各种形式的生姜补充剂（胶囊、粉末、饼干），并将它们与安慰剂、维生素B6和胃复安等对照物进行比较。汇总比值比为0.41（95%CI：0.22-0.79，P=0.008），表明恶心和呕吐症状显著减轻。补充生姜耐受性良好，副作用最小，对母婴健康无显著危害。该分析支持在临床实践中将生姜作为治疗妊娠剧吐症状的一种安全、灵活且有效的非药物疗法。
