Li Zhiqiang, Yu Yang, Chen Baozhong
First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Harbin 150040, Heilongjiang, China.
Heilongjiang Open University Harbin 150006, Heilongjiang, China.
Am J Transl Res. 2025 Mar 15;17(3):1756-1767. doi: 10.62347/NFKV1920. eCollection 2025.
To investigate the clinical effect of anti-platelet aggregation drugs combined with Shujin Huoluo Decoction (SJHLD, a decoction for relaxing muscles and activating collaterals) in the treatment of diabetic peripheral vascular disease.
A total of 130 patients with diabetic peripheral vascular disease were retrospectively included in this study and divided into two groups. In the monotherapy group, 65 patients were treated with cilostazol (CTZ) monotherapy; in the combined group, 65 patients were treated with CTZ combined with SJHLD. The treatment efficacy, inflammatory indexes, blood glucose and lipid levels, ultrasound parameters, and hemorheology of the two groups were compared before and after treatment.
Both groups showed significant improvements in walking distance and skin temperature of the toes, with more pronounced changes observed in the combined group ( < 0.05). After treatment, inflammatory markers decreased notably in both groups ( < 0.05). Blood glucose and lipid levels decreased markedly, with a more substantial reduction in lipid levels observed in the combined group ( < 0.05). Lower limb arterial conditions improved markedly in both groups, with greater improvements seen in the combined group ( < 0.05). Additionally, the pulsatile index and blood flow velocity in the ankle-brachial and dorsalis pedis arteries increased markedly in both groups, with the combined group showing a greater improvement ( < 0.05). Hemorheology parameters also decreased significantly in both groups, with the combined group showing a more significant reduction ( < 0.05). The effective treatment rate was significantly higher in the combined group ( < 0.05).
The combination of CTZ and SJHLD significantly improves lower limb function, ultrasound parameters, and blood flow, enhancing treatment efficiency in patients with diabetic peripheral vascular disease. This therapeutic approach offers valuable clinical guidance and warrants consideration for use in diabetic patients.
探讨抗血小板聚集药物联合舒筋活络汤治疗糖尿病周围血管疾病的临床疗效。
回顾性纳入130例糖尿病周围血管疾病患者，分为两组。单药治疗组65例患者采用西洛他唑单药治疗；联合治疗组65例患者采用西洛他唑联合舒筋活络汤治疗。比较两组治疗前后的治疗效果、炎症指标、血糖和血脂水平、超声参数及血液流变学。
两组患者的步行距离和足趾皮肤温度均有显著改善，联合治疗组变化更明显（<0.05）。治疗后，两组炎症标志物均显著下降（<0.05）。血糖和血脂水平显著降低，联合治疗组血脂水平下降更显著（<0.05）。两组下肢动脉状况均显著改善，联合治疗组改善更明显（<0.05）。此外，两组踝肱动脉和足背动脉的搏动指数和血流速度均显著增加，联合治疗组改善更明显（<0.05）。两组血液流变学参数也显著降低，联合治疗组降低更显著（<0.05）。联合治疗组的有效治疗率显著更高（<0.05）。
西洛他唑与舒筋活络汤联合应用可显著改善下肢功能、超声参数和血流，提高糖尿病周围血管疾病患者的治疗效率。这种治疗方法提供了有价值的临床指导，值得考虑用于糖尿病患者。
