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本文引用的文献

1
Follicular dendritic cell sarcoma.滤泡树突状细胞肉瘤。
Pathologica. 2021 Oct;113(5):316-329. doi: 10.32074/1591-951X-331.
2
Follicular Dendritic Cell Sarcoma.滤泡性树突状细胞肉瘤
Arch Pathol Lab Med. 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS.
3
Follicular dendritic cell tumor: report of 13 additional cases of a distinctive entity.滤泡树突状细胞瘤：另外13例独特实体病例报告。
Am J Surg Pathol. 1996 Aug;20(8):944-55. doi: 10.1097/00000478-199608000-00003.

颈部淋巴结滤泡树突状细胞肉瘤的罕见儿科表现：一例报告

Rare Paediatric Presentation of Follicular Dendritic Cell Sarcoma of Cervical Lymph Node: A Case Report.

作者信息

Chakravarty Sharmistha, Bharadwaj Kritika, Banjare Amit

机构信息

Department of ENT & Head Neck Surgery, All India Institute of Medical Sciences, G.E Road, Tatibandh, Raipur, 492099 Chhattisgarh India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2025 Apr;77(4):1955-1958. doi: 10.1007/s12070-025-05443-2. Epub 2025 Apr 2.

DOI:10.1007/s12070-025-05443-2
PMID:40226264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11985710/
Abstract

BACKGROUND

Follicular dendritic cell sarcoma (FDCS) is an uncommon malignancy of mesenchymal origin, arising from follicular dendritic cells of the immune system. It commonly manifests at extranodal sites, and cervical lymph nodes are rarely involved [1]. These cells mainly reside in B- follicles, boosting adaptive immune response. It typically presents in middle-aged adults with no sex predisposition and has a low incidence in pediatric populations.

CASE REPORT

  • We present a unique case of FDCS in a 14-year-old female who developed a right-sided neck mass that persisted for a year. Imaging revealed a well-defined heterogeneous lesion in the right cervical region involving level IIb and III lymph nodes. Surgical excision via a transcervical approach was performed. Histopathology and immunohistochemistry confirmed the diagnosis of follicular dendritic cell sarcoma.

CONCLUSION

  • This case highlights the uncommon age and site of presentation. FDCS of cervical lymph node in a young child forms an important differential diagnosis in patients with malignant cervical mass. Locoregional spread, surgical resectability and histopathological findings are significantly associated with the outcome.
摘要

背景

滤泡性树突状细胞肉瘤（FDCS）是一种罕见的间叶源性恶性肿瘤，起源于免疫系统的滤泡性树突状细胞。它通常发生于结外部位，很少累及颈部淋巴结[1]。这些细胞主要存在于B滤泡中，促进适应性免疫反应。它通常发生于中年成年人，无性别倾向，在儿童人群中的发病率较低。

病例报告

我们报告一例独特的FDCS病例，患者为一名14岁女性，右侧颈部肿块持续一年。影像学检查显示右侧颈部区域有一个边界清晰的异质性病变，累及Ⅱb和Ⅲ级淋巴结。通过经颈入路进行了手术切除。组织病理学和免疫组织化学检查确诊为滤泡性树突状细胞肉瘤。

结论

该病例突出了发病年龄和部位的罕见性。幼儿颈部淋巴结的FDCS是恶性颈部肿块患者重要的鉴别诊断。局部扩散、手术可切除性和组织病理学结果与预后显著相关。