Parab Sapna Ramkrishna, Khan Mubarak Muhamed, Ingale Mayur, Patel Neel, Gurjar Medha, Shinde Vinod
Sushrut ENT Hospital and Dr. Khan's Research Center, Talegaon Dabhade, India.
Department of ENT, Hospital and Research Centre, Dr DY Patil Medical college, Dr DY Patil Vidyapeeth, Pimpri, Pune India.
Indian J Otolaryngol Head Neck Surg. 2025 Apr;77(4):1964-1968. doi: 10.1007/s12070-025-05421-8. Epub 2025 Mar 24.
Platelet rich fibrin (PRF) is known for regenerative properties and therapeutic potential in various medical and surgical conditions. In Otorhinolaryngology, PRF has been documented for use in repair of traumatic perforations. It has shown to accelerate healing, reduce inflammation, and improve tissue regeneration. PRF, with its higher concentration of growth factors, offers prolonged benefits in tissue repair and regeneration. This study introduces a novel technique for preparing PRF sheets and investigates their potential to enhance outcomes in endoscopic middle ear surgery, with a particular focus on healing and graft integration. We describe in detail a novel technique for preparing PRF sheets and propose their application in middle ear surgery. Clinical observations focused on epithelialization, graft integration, and the overall healing process of the mastoid cavities following surgery. The use of PRF sheets resulted in healthy epithelization and successful graft intake. Additionally, early epithelization of mastoid cavities was observed, demonstrating the therapeutic efficacy of PRF sheets in promoting tissue regeneration. The application of PRF sheets during middle ear surgery shows promising results, offering a novel approach for enhancing healing and improving clinical outcomes in endoscopic procedures. Further studies are needed to confirm these findings and optimize the technique. Level 4.
The online version contains supplementary material available at 10.1007/s12070-025-05421-8.
富血小板纤维蛋白（PRF）以其在各种医学和外科病症中的再生特性和治疗潜力而闻名。在耳鼻咽喉科，PRF已被记录用于外伤性穿孔的修复。它已显示出能加速愈合、减轻炎症并改善组织再生。PRF因其更高浓度的生长因子，在组织修复和再生方面具有长期益处。本研究介绍了一种制备PRF片的新技术，并研究其在内镜中耳手术中改善手术效果的潜力，特别关注愈合和移植物整合情况。我们详细描述了一种制备PRF片的新技术，并提出其在中耳手术中的应用。临床观察集中在术后乳突腔的上皮化、移植物整合以及整体愈合过程。PRF片的使用导致了健康的上皮化和成功的移植物摄取。此外，观察到乳突腔的早期上皮化，证明了PRF片在促进组织再生方面的治疗效果。在中耳手术中应用PRF片显示出有前景的结果，为在内镜手术中促进愈合和改善临床效果提供了一种新方法。需要进一步研究来证实这些发现并优化该技术。 4级。
在线版本包含可在10.1007/s12070-025-05421-8获取的补充材料。
