Zheng Kanghua, Hong Xiaoping, Jiang Changyin, Chen Yong
Department of Rehabilitation, The Second People's Hospital Affiliated to Fujian University of Chinese Medicine Fuzhou 350003, Fujian, China.
Department of Pathophysiology, College of Integrative Medicine, Fujian University of Traditional Chinese Medicine Fuzhou 350122, Fujian, China.
Am J Cancer Res. 2025 Mar 15;15(3):991-1001. doi: 10.62347/YXHG6188. eCollection 2025.
This study aims to evaluate the effects of warm acupuncture combined with conventional functional rehabilitation training (FRT) on the recovery of breast cancer (BC) patients following radical mastectomy, focusing on immune function, pain management, and quality of life (QoL). This retrospective study involved 118 BC patients who underwent radical surgery at the Second People's Hospital Affiliated to Fujian University of Chinese Medicine between January 2022 and May 2024. The included patient were assigned into an experimental group (EG, n=62, warm acupuncture in conjunction with conventional FRT) and a control group (CG; n=56; conventional FRT only). Postoperative outcomes, including surgery duration, intraoperative blood loss (IOBL), drainage volume (DV), length of hospital stay, upper limb mobility, immune function indicators, and pain scores, were compared between the two groups. Multivariate logistic regression was employed to identify factors affecting treatment outcomes. The EG demonstrated significantly lower visual analog scale (VAS) scores at post-operative 2, 4, and 8 weeks compared to the CG (all < 0.05). The incidence of upper limb lymphedema in the EG was 9.26%, notably lower than the 24.07% observed in the CG ( < 0.05). Immune function indicators, including CD3, CD4, CD8, and the CD4/CD8 ratio, were significantly higher in the EG postoperatively ( < 0.05). Furthermore, the EG reported significantly improved scores in role physical, general health, vitality, social functioning, role emotional, mental health, and physiological functioning, alongside significantly lower scores in bodily pain compared to the CG (all < 0.05). Multivariate logistic regression analysis revealed CD3 and CD4/CD8 ratio as independent factors affecting patient treatment efficacy (both < 0.05). In conclusion, the combination of warm acupuncture and conventional FRT significantly enhances immune function, pain management, and overall QoL in BC patients after surgery, with CD3 and CD4/CD8 ratios being crucial factors influencing recovery.
本研究旨在评估温针灸联合传统功能康复训练（FRT）对乳腺癌（BC）根治术后患者恢复的影响，重点关注免疫功能、疼痛管理和生活质量（QoL）。这项回顾性研究纳入了2022年1月至2024年5月期间在福建中医药大学附属第二人民医院接受根治性手术的118例BC患者。纳入的患者被分为实验组（EG，n = 62，温针灸联合传统FRT）和对照组（CG；n = 56；仅接受传统FRT）。比较了两组患者的术后结果，包括手术时长、术中失血量（IOBL）、引流量（DV）、住院时间、上肢活动度、免疫功能指标和疼痛评分。采用多因素逻辑回归分析确定影响治疗效果的因素。与CG组相比，EG组在术后2周、4周和8周时的视觉模拟量表（VAS）评分显著更低（均P < 0.05）。EG组上肢淋巴水肿的发生率为9.26%，明显低于CG组的24.07%（P < 0.05）。术后EG组的免疫功能指标，包括CD3、CD4、CD8及CD4/CD8比值，均显著更高（P < 0.05）。此外，与CG组相比，EG组在角色生理、总体健康、活力、社会功能、角色情感、心理健康和生理功能方面的评分显著提高，而在身体疼痛方面的评分显著更低（均P < 0.05）。多因素逻辑回归分析显示，CD3和CD4/CD8比值是影响患者治疗效果的独立因素（均P < 0.05）。综上所述，温针灸与传统FRT相结合可显著提高BC患者术后的免疫功能、疼痛管理能力及总体生活质量，CD3和CD4/CD8比值是影响恢复的关键因素。
